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shs912vv

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[求助] 求細(xì)胞免疫相關(guān)的大神翻譯3小段和肝再生細(xì)胞通路有關(guān)的話（已被精簡(jiǎn)）

1.Foxm1b在肝細(xì)胞再生G1/S相表達(dá)顯著增強(qiáng), Foxm1b對(duì)細(xì)胞增殖的影響主要通過(guò)調(diào)控Skp2和Cks1編碼Skp-Cullin1-F-box(SCF)泛素連接酶復(fù)合物的亞基, 靶向作用于CDK抑制蛋白P21CIP1/WAF1、p27Kip在G1/S相轉(zhuǎn)換中降解, 進(jìn)而影響某些Cyclin或Cdk活化劑Cdc25a、Cdc25b磷酸酶的活性, 同時(shí)他又能激活JNK1,共同調(diào)控G1/S的轉(zhuǎn)變. Foxm1b還參與生長(zhǎng)激素(growth hormone, GH)介導(dǎo)的細(xì)胞增殖.
2.TGR5可于Kupffer細(xì)胞表面表達(dá), 活化后可誘導(dǎo)細(xì)胞內(nèi)胞內(nèi)環(huán)磷腺苷(cyclic adenosine monophosphate,cAMP)升高, 可通過(guò)激活TGR5-cAMP途徑改善Kupffer細(xì)胞免疫功能, 抑制其產(chǎn)生過(guò)量的炎癥細(xì)胞因子而影響肝再生.
3.MAPKs是一類絲氨酸/蘇氨酸蛋白激酶, 可調(diào)節(jié)細(xì)胞增殖、凋亡等反應(yīng). MAPKs主要包括ERK、c-Jun氨基末端激酶(c-Jun NH2-terminal kinase, JNK)和p38MAPK通路,其中JNK和p38MAKP被稱為應(yīng)激活化蛋白激酶,. 有研究顯示, 低濃度膽酸可使肝細(xì)胞JNK蛋白顯著上調(diào), 而高濃度的膽酸則使p38MAPK蛋白表達(dá)顯著上調(diào), 提示不同濃度的膽汁酸對(duì)肝再生的不同作用可能是通過(guò)調(diào)節(jié)JNK和p38MAKP途徑實(shí)現(xiàn)的.

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1樓 2013-10-27 11:05:13

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leilejiayou

木蟲 (正式寫手)

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【答案】應(yīng)助回帖

★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ...
shs912vv: 金幣+120, 翻譯EPI+1, ★★★★★最佳答案, 好厲害，基本是翻譯出來(lái)的，還有少部分可能微調(diào)，而且大神貌似是跨專業(yè)的翻譯哎~佩服佩服 2013-10-27 12:51:42

1.Foxm1b in regeneration G1 / S phase was significantly enhanced, Foxm1b mainly impacts on cell proliferation by regulating Skp2 and Cks1 in coding complex subunits of Skp-Cullin1-F-box (SCF) ubiquitin and ligase , targeting at the CDK to inhibit degradation of protein P21CIP1/WAF1, p27Kip in G1 / S phase conversion, thereby affecting activity certain Cyclin or Cdk activator Cdc25a, Cdc25b phosphatase, and he can activate JNK1, jointly regulate the transition of G1 / S. Foxm1b is also involved in process of the growth hormone (growth hormone, GH) mediating cell proliferation.
2.TGR5 can express on the surface of Kupffer cells , and after activation it can induce cell intracellular cyclic adenosine monophosphate (cyclic adenosine monophosphate, cAMP) to increase, by activating TGR5-cAMP pathway to improve the immune function of Kupffer cells to inhibit inflammatory cells to produce excessive factors affecting liver regeneration.
3.MAPKs are a class of serine / threonine protein kinase that regulates cell proliferation, apoptosis and other reactions. MAPKs mainly includ ERK, c-Jun N-terminal kinase (c-Jun NH2-terminal kinase, JNK) and p38MAPK pathway, among which JNK and p38MAKP are called stress-activated protein kinase. Studies have shown that low concentrations of acid can make JNK in liver cells increase significantly , while the high concentration of acid make the expression of p38MAPK protein significantly increase, suggesting that different concentrations of bile acids may effect on liver regeneration differently by regulating JNK and p38MAKP.
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既然選擇了，就堅(jiān)持下去！

2樓2013-10-27 12:24:33

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