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[資源]
prog. polym. sci.上online的一篇關(guān)于熒光納米生物成像探針的綜述,喜歡的拿走
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來自北京化工大學(xué)材料科學(xué)與工程學(xué)院的尹梅貞教授課題組發(fā)表了題為“Design and development of fluorescent nanostructures for bioimaging”的綜述,該綜述發(fā)表在國際頂級綜述期刊Progress in Polymer Science雜志上(IF=26.38)。 熒光技術(shù)是一種具備了靈敏性、特異性、便利性、多樣性等特點(diǎn)的新興科技,上述特點(diǎn)使其在生物成像方面具有十分廣泛的應(yīng)用。同時(shí),納米材料具有尺寸小的特征,而由此產(chǎn)生的納米效應(yīng)使得材料自身在光學(xué)、熱學(xué)等物理性能方面都有顯著的提高。由以上兩種技術(shù)結(jié)合的熒光生物成像納米探針倍受到科研工作者的關(guān)注,并被廣泛應(yīng)用于生命科學(xué)等諸多領(lǐng)域,具有重要的學(xué)術(shù)價(jià)值以及廣闊的應(yīng)用開發(fā)前景。 這篇綜述從熒光納米結(jié)構(gòu)的組成角度出發(fā),將其分為有機(jī),無機(jī)和有機(jī)/無機(jī)雜化三大類,全面歸納闡述了近年來國內(nèi)外報(bào)道的各種類型熒光納米結(jié)構(gòu)在生物成像方面的應(yīng)用。同時(shí)簡單討論了各種熒光探針納米結(jié)構(gòu)的發(fā)光機(jī)理以及應(yīng)用設(shè)計(jì)思路。將熒光納米技術(shù)與生命科學(xué)有機(jī)結(jié)合不但充分體現(xiàn)了學(xué)科交叉的重要意義,還使得人們在納米尺度甚至單分子水平上獲取生命過程生物化學(xué)信息,可以對單細(xì)胞進(jìn)行原位、實(shí)時(shí)、動態(tài)分析以及定向捕獲和分離等等。 文章的通訊作者是北京化工大學(xué)的高層次引進(jìn)人才尹梅貞教授,第一作者為尹梅貞教授課題組的博士研究生陳夢君。該綜述得到了國家自然科學(xué)基金,教育部新世紀(jì)優(yōu)秀人才支持計(jì)劃等基金資助。 送審過程中,審稿人也給予了很高評價(jià): Referee 1: Good review on an interesting field that is a hot topic. As a review this is a valuable paper. Referee 2: Although there are now many reviews on this topic, this is the first to incorporate, classify and compare nearly all of the fluorescent nanostructures to date. As such the review offers reader a comprehensive, one-stop review showing the complete toolset for bioimaging. 該篇Progress in Polymer Science綜述目前為online狀態(tài),其DOI為http://dx.doi.org/10.1016/j.progpolymsci.2013.11.001 綜述的摘要如下: Because fluorescence-based techniques are inherently sensitive, selective, convenient, diverse, non-destructive, potentially real time and in situ, they have been widely used in biological imaging. Especially those, with specific fluorescent nanostructures (FNSs) as detecting media in bioimaging, have already been intensively studied for more than a decade because of the convenient transduction of optical signal, high sensitivity and rapid response of FNSs. In this review, we summarize the major strategies to design FNSs with specific structures for biological imaging. First, recent advances are briefly introduced. Then, the specific design of FNSs and their applications are reviewed, in which their fluorescence mechanism, strategies in designing and development, preparation methods, and some representative applications in bioimaging are described. Finally, future perspectives and ongoing issues of FNSs and their applications in bioimaging are discussed. Although many FNSs have been synthesized and applied biologically, many studies still should be done before they can be widely employed as fluorescent probes in clinical tests. With further advances in design and synthesis of high quality multifunctional FNSs, the widespread application of FNSs may be expected not only in advanced bioimaging, but also in ultra-sensitive molecular diagnosis, novel light-emitting nanodevices and intracellular drug delivery. |
Nano&Micro | Fluorescent Nanomaterials | reviews paper | 科研啊 努力啊 希望有用啊 |
納米材料 | 探針 |
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