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clavichord新蟲 (小有名氣)
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[求助]
求翻譯一句話?
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| We show that nonmuscle MIIB (myosin-IIB) is unpolarized in cells on soft matrix in 2D and also within soft 3D collagen, with rearward polarization of MIIB emerging only as cells migrate from soft to stiff matrix. Durotaxis is the tendency of cells to crawl from soft to stiff matrix, and durotaxis of primary mesenchymal stem cells (MSCs) proved more sensitive to MIIB than to the more abundant and persistently unpolarized nonmuscle MIIA。 |
版主 (文壇精英)
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我們發(fā)現(xiàn),在2D和3D膠原蛋白軟基質中的細胞上的非肌肉MIIB(肌球蛋白-IIB)是非極性的,僅當細胞從軟到硬基質遷移時發(fā)生MIIB極化。 Durotaxis是細胞從軟到硬基質行進的傾向,初級間充質干細胞(MSCs)的durotaxis證明對MIIB比更豐富、更難以極化的非肌肉MIIA更敏感。 durotaxis:趨硬性。duro拉丁文硬的,taxis是生物的趨性,結合相關文獻---cell prefers to migrate towards stiffer regions on a substrate with a stiffness gradient,the phenomenon is called durotaxis |

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