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The synthesis of a series of 3-aryl pyrazolo[4,3-d]pyrimidines as potential corticotropin-releasing factor (CRF-1) antagonists is described. The effects of substitution on the aromatic ring, the amino group and the pyrazolo ring on CRF-1 receptor binding were investigated. # 2002 Elsevier Science Ltd. All rights reserved. |
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corticotropin-releasing factor 腎上腺皮質(zhì)激素釋放因子 3-aryl pyrazolo[4,3-d]pyrimidines 3 - 芳基吡唑并[ 4,3 -D]嘧啶 antagonist an.tag.o.nist AHD: [2n-t2g“…-n1st] D.J. [#n6t#g*n!st] K.K. [#n6t#g*n!st] n.(名詞) 1. One who opposes and contends against another; an adversary.See Synonyms at opponent 對(duì)抗者,對(duì)手,敵手:反對(duì)另一人及與另一人競(jìng)爭(zhēng)的人;對(duì)手參見(jiàn) opponent 2. The principal character in opposition to the protagonist or hero of a narrative or drama. 反面主角:敘事文學(xué)或戲劇中與主人公或英雄相對(duì)立的主要人物 3. Physiology A muscle that counteracts the action of another muscle, the agonist. 【生理學(xué)】 拮抗肌,對(duì)抗。旱窒∪庾饔玫牧硪粔K肌肉,收縮肌 4. Biochemistry A chemical substance that interferes with the physiological action of another, especially by combining with and blocking its nerve receptor. 【生物化學(xué)】 拮抗藥,對(duì)抗藥:通過(guò)與另一種化學(xué)物質(zhì)的結(jié)合或阻礙其神經(jīng)接受體而干擾其生理作用的一種化學(xué)物質(zhì) 【生物化學(xué)】 拮抗藥,對(duì)抗藥:通過(guò)與另一種化學(xué)物質(zhì)的結(jié)合或阻礙其神經(jīng)接受體而干擾其生理作用的一種化學(xué)物質(zhì) 【生物化學(xué)】 拮抗藥,對(duì)抗藥:通過(guò)與另一種化學(xué)物質(zhì)的結(jié)合或阻礙其神經(jīng)接受體而干擾其生理作用的一種化學(xué)物質(zhì) To trace the form or outline of: 沿著…畫(huà): describe a circle with a compass. 用圓規(guī)畫(huà)一個(gè)圓 substitution on the aromatic ring 取代在芳環(huán)上 amino group the univalent [一價(jià)的, (尤指染色體) 單價(jià)的] group, -NH2. Also called amino radical. pyrazolo ring pyrazolo ring 吡唑環(huán) pyrazol [ ] [醫(yī)] 吡唑, 鄰二氮雜茂 corticotropin releasing factor Biochem. a hormonelike factor, produced by the hypothalamus[下丘腦], that stimulates the increased release of corticotropin by the pituitary gland in response to stress. Abbr.: CRF Anatomy A large ovoid mass of gray matter situated in the posterior part of the forebrain that relays sensory impulses to the cerebral cortex. 【解剖學(xué)】 丘腦:將感覺(jué)沖動(dòng)傳入大腦皮層的位于前腦后部的大卵圓形灰質(zhì)塊 【解剖學(xué)】 丘腦:將感覺(jué)沖動(dòng)傳入大腦皮層的位于前腦后部的大卵圓形灰質(zhì)塊 【解剖學(xué)】 丘腦:將感覺(jué)沖動(dòng)傳入大腦皮層的位于前腦后部的大卵圓形灰質(zhì)塊 2. Botany The receptacle of a flower. 【植物學(xué)】 花托 語(yǔ)源: 1. Latin [inner chamber] 拉丁語(yǔ) [內(nèi)腔] 2. from Greek thalamos 源自 希臘語(yǔ) thalamos |
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