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wangying2121金蟲(chóng) (小有名氣)
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[求助]
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| 請(qǐng)問(wèn)有誰(shuí)可以幫忙改改我的SCI論文的英語(yǔ)語(yǔ)言呢，可以掛名，非常感謝！ |
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wangying2121
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2樓2013-12-18 13:33:20
flzf890789
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3樓2013-12-24 15:14:49
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4樓2013-12-26 11:16:23
wangying2121
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HMGB1 played a role in both intranuclear and extracellular molecular functions. In intranuclear, HMGB1 took part in regulating transcription, DNA repair and recombination process[26]. In extracellular, it take part in mediating cytokine of inflammation[27], it mediated the response to infection and injury by binding with series receptors including the receptor for advanced glycation end products(RAGE) promoting inflammation[28]. Evidences showed that HMGB1 played significant roles in infection, tissue injury, inflammation, apoptosis, and immune response, some of which were associated with cancer or inflammatory diseases[20, 21, 29]. Studies suggested that HMGB1 contributed to the development of several cancers by regulating all the hallmarks of cancer development such as cell proliferation, apoptosis, angiogenesis, migration and invasion[30]. HMGB1 can also strengthen the activities of some transcription factors involved in cancer development, such as p53[31-33], p73[34], (NF)κB[35], the retinoblastoma protein[36], and estrogen receptor[37]. In lung cancers, RAGE-HMGB1 was not overexpressed like most other cancers. Loss expression of it can regulate tumor migration and invasive processes which were correlated to the aggressivity of tumor cells[38]. Several therapeutic methods had been considered based on blocking the RAGE-HMGB1 signaling and some other pathways involved in promoting inflammation after HMGB1 signaling[39]. Increasing the expression of HMGB1 can increase the cisplatin sensitivity for MCF-7 breast cancer line[40]. However, the association between HMGB1 SNPs and chemotherapy response had not been reported yet. |
5樓2013-12-27 17:44:06
bw207
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6樓2013-12-28 20:58:54
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7樓2013-12-29 21:04:51
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