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cainiaodui新蟲 (小有名氣)
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[求助]
求助翻譯
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In addition to tumor studies using anti-DLL4 as a single agent, additive anti-tumor activity was observed in combination with anti-VEGF therapy in a majority of tested tumor models. Since angiogenic sprouting after DLL4 blockade remains a VEGF-dependent process , DLL4 inhibition may increase the dependency of the tumor microvasculature on a VEGF-mediated survival signal. In anti-Dll4 treated neonatal mouse retinas, there was a defect in arteriogenesis with a complete absence of pericyte coverage of the retinal vessels . Soluble DLL4 was also able to reduce the recruitment of pericytes in a murine xenograft tumor model. |
銀蟲 (小有名氣)
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除了將抗-DLL4作為單藥用于腫瘤研究外,同時(shí)觀察了抗腫瘤活性的添加劑聯(lián)合抗-VEGF治療在大部分腫瘤測(cè)試模型中的作用。DLL4抑制血管生成后仍然保持依賴VEGF的過程,DLL4抑制可能增加腫瘤微血管上VEGF介導(dǎo)的存活信號(hào)的依賴性。在抗DLL4處理的新生小鼠視網(wǎng)膜上,在動(dòng)脈中存在視網(wǎng)膜血管完全沒有周細(xì)胞覆蓋的缺陷?扇苄缘腄LL4還能夠降低周細(xì)胞在小鼠異種移植瘤模型中的聚集。 新手翻譯,請(qǐng)多指教~ |
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