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題目:Design, synthesis and characterization of 3-alkyl substituted chlorin derivatives 期刊:Journal of Chemical and Pharmaceutical Research(ISSN:0975-7384) 作者:Bing Cun Cui, Xin Yu,Dong Mei Ni, Yuan Dong Lu, Il Yoon and Young Key Shim |
版主 (文學泰斗)
風雪
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恭喜被收錄了 Accession number: 20140517244846 Title: Design, synthesis and characterization of 3-alkyl substituted chlorine derivatives Authors: Cui, Bing Cun1, 2; Yu, Xin1; Ni, Dong Mei1; Lu, Yuan Dong1; Yoon, I.L.2; Shim, Young Key2 Author affiliation: 1 College of Medicine, Hubei Polytechnic University, Huangshi, China 2 PDT Research Institute, School of Nano System Engineering, Inje University, Gimhae, Korea, Republic of Source title: Journal of Chemical and Pharmaceutical Research Abbreviated source title: J. Chem. Pharm. Res. Volume: 5 Issue: 12 Issue date: 2013 Publication year: 2013 Pages: 776-781 Language: English E-ISSN: 09757384 Document type: Journal article (JA) Publisher: Journal of Chemical and Pharmaceutical Research, 3/668 Malviya Nagar, Jaipur, Rajasthan, India Abstract: The novel 3-alkyl substituted chlorin derivatives exhibiting good lipophilicity were obtained from methyl pheophorbide-a by modification of the peripheral functional groups. The vinyl group at 3-position was oxidized with OsO4 and NaIO4 to form the formyl group and the Grignard reaction of this aldehyde with the alkyl magnesium bromide was carried out to give the corresponding 3-(1-hydrroxylalkyl) pheophorbide-a. The 3-(1-hydrroxylalkyl) functional group was converted into 3-alkyl chain by dehydration and hydrogenation. The Qy band of prepared photosensitizers were affected by the substituent on the Qy axis (N21-N23). The structures of new photosensitizers were characterized by elemental analysis, UV-vis and 1H NMR spectra. Number of references: 13 Main heading: Photosensitizers Controlled terms: Complexation - Functional groups - Nuclear magnetic resonance spectroscopy - Photodynamic therapy - Synthesis (chemical) Uncontrolled terms: Chlorins - Formyl group - Grignard reaction - H NMR spectra - Lipophilicity - Magnesium bromide - Methyl pheophorbide-a - Synthesis and characterizations Classification code: 741.1 Light/Optics - 802.2 Chemical Reactions - 804.1 Organic Compounds - 932.2 Nuclear Physics Database: Compendex Compilation and indexing terms, © 2013 Elsevier Inc. Full-text and Local Holdings Links |
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