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瀟雪Puff金蟲 (小有名氣)
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[求助]
求翻譯exhaustion marker的意思,謝謝
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Tc9 Cells Are Less Exhausted and Developed into Full Effector Cells in Vivo. Tc9 cells had significantly down-regulated expression of the exhaustion markers, such as KLRG-1, PD-1, LAG3, and 2B4 (Fig. 4B), demonstrating that Tc9 cells were less exhausted T cells even upon repeated activation in vivo. |
版主 (文壇精英)

版主 (文壇精英)
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exhaustion marker 衰竭性表面標(biāo)志物 Tc9 Cells Are Less Exhausted and Developed into Full Effector Cells in Vivo. TC9細(xì)胞是很少衰竭,在體內(nèi)發(fā)展成為全效應(yīng)細(xì)胞。 Tc9 cells had significantly down-regulated expression of the exhaustion markers, such as KLRG-1, PD-1, LAG3, and 2B4 (Fig. 4B), demonstrating that Tc9 cells were less exhausted T cells even upon repeated activation in vivo. TC9細(xì)胞衰竭表面標(biāo)志物表達(dá)顯著下調(diào),比如KLRG-1,PD-1,LAG3和2B4(圖4B)的表達(dá)。這表明TC9細(xì)胞很少衰竭,那怕在體內(nèi)反復(fù)激活。 衰竭性CD8+T細(xì)胞。這群細(xì)胞表面持續(xù)性高表達(dá)PD-1抑制性受體,除了PD1以外,抗原特異性的CD8+T細(xì)胞表面還共表達(dá)CD244 (2B4), LAG-3, CD160,TIM-3, CTLA-4和以及其他抑制性受體。 (((PD1已被公認(rèn)為是衰竭性T淋巴細(xì)胞的表面標(biāo)志。))) 研究發(fā)現(xiàn)在慢性感染性疾病中,阻斷PD1和 CTLA-4、PD1和LAG-3、PD1和Tim-3可以部分恢復(fù)CD8+T細(xì)胞的生物學(xué)功能,此 外,研究發(fā)現(xiàn)對于腫瘤抗原特異性的CD8+T細(xì)胞,阻斷PD1和Tim-3,或者PD-1和LAG-3,可以部分恢復(fù)CD8+T細(xì)胞功能。盡管阻斷這些通路后可以部分恢復(fù)衰竭性T細(xì)胞的功能,但還是不能使這些衰竭性T細(xì)胞逆轉(zhuǎn)成非衰竭性T細(xì)胞,從而導(dǎo)致腫瘤復(fù)發(fā)、轉(zhuǎn)移等,不能達(dá)到根治的目的。 |

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