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| This suggests that the effects of Notch decoy differs from the effects on angiogenesis following the sole inhibition of Dll4–Notch signaling, perhaps reflecting that, in this case, Jagged1 was also blocked. These stud-ies emphasize that blocking Notch signaling is appealing as an alternative antiangiogenic strat-egy. For instance, we refer back to the observation in breast cancer, in which high levels of Notch1 have been shown to promote tumorigenesis. |
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