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wzg389960金蟲 (小有名氣)
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[求助]
英文文獻(xiàn)翻譯
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A number of investigations have been conducted in the past two decades to improve the understanding of the therapeutic prospects of GST. The involvement of GST in drug resistances has created an alternative target in the enhancement of potency of therapeutic agents. A rationale has been established to utilize agents that selectively inhibit the various classes of GST as adjuvant in anticancer chemo- therapy and as antiparasitic drugs. This concept was formu- lated in a bid to discover compounds that can inactivate GST for enhanced activity of the desired drug. These agents could act by either inhibiting the catalytic activity of GST in metabolism of electrophilic drugs [28] or in disruption of the complex formed between GST and stress signal kinases 。 |

金蟲 (小有名氣)

木蟲 (小有名氣)
| 過去的二十年中,人們進(jìn)行大量的調(diào)查研究以提升大眾對于GST治療前景的了解。耐藥性中GST的引入在增強(qiáng)藥力方面提供了一個(gè)可選擇的目標(biāo)。我們已經(jīng)建立了一個(gè)理論基礎(chǔ)來利用藥劑使其選擇性的抑制各級GST,就像癌癥化療中所使用的輔藥或者像打蟲藥。這個(gè)觀點(diǎn)被表述在標(biāo)書(bid的意思搞不清)中以發(fā)現(xiàn)可以使GST失活從而增強(qiáng)所需藥品藥力的化合物。這些藥劑可以通過以下兩種方式起作用:1.抑制GST對于親電藥物反代謝作用的催化活性。2.中斷GST和應(yīng)激信號激酶復(fù)合物的形成過程。 |
金蟲 (小有名氣)

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