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RXMCDM: 金幣+1, 多謝應(yīng)助！ 2014-03-14 00:56:23
wzg389960: 金幣+20, 翻譯EPI+1, ★★★很有幫助 2014-03-15 05:21:46
GSTs are divided into two groups: the membrane-bound microsomal and the cytosolic GSTs.
GST被分為兩組：膜結(jié)合的微粒體GST和胞漿GST。
Microsomal GSTs exist in homo- and hetero-trimerized forms with a single active site and function in the endogenous metabolism of leucotrienes and prostaglandins [8].
微粒體GST以同三聚體或異三聚體形式存在，它只有一個(gè)活性中心，并在白細(xì)胞三烯和前列腺素的胞內(nèi)代謝中起作用。
In humans, cytosolic GSTs exist in the form of various dimerized isoenzyme classes: (A), μ (M), , (P), (T), (Z) and classes[8,13].
在人類中，胞漿GST以多種二聚體同工酶形式存在：（略）。
Their existence in different forms has provided broad substrate specificities promoting detoxification of many toxic substances.
不同形式的胞漿GST的存在為其提供了寬泛的特異性底物范圍，這促進(jìn)了許多種有毒底物的解毒作用。
Recently, the X-ray crystal structure of GST of the malaria-causing parasite, Plasmodium falciparum, was elucidated [14].
最近導(dǎo)致瘧疾的寄生蟲——惡性瘧原蟲的GST的X射線晶體結(jié)構(gòu)得到了闡明。
The isoenzymes of GST are related in their aminoacid constituents and a little in their conformation except at specific regions, two of which are needed for activity.
GST的同工酶在其氨基酸組成上相互關(guān)聯(lián)，除了在特定區(qū)域之外，其構(gòu)象也相互關(guān)聯(lián)，其中兩個(gè)特定區(qū)域?qū)τ谄浠钚允潜匦璧摹?br />
This distinguishing uniqueness is attributed to the catalytic hydrophobic site (H-site) and a glutathione-binding site (G-site), which offer diversity in specificities of the different isoenzymes for different substrates.
這種造成區(qū)別的獨(dú)特性屬于催化性的疏水位點(diǎn)（H位點(diǎn)）和一個(gè)谷胱甘肽結(jié)合位點(diǎn)（G位點(diǎn)），它們?yōu)椴煌っ笇Σ煌孜锏奶禺愋蕴峁┝硕鄻有浴?br />
In addition to their xenobiotic detoxification roles, human and parasitic GSTs have been implicated as lead actors in cellular drug resistances, which is a major factor in the failure of chemotherapy [15].
除了對異生物質(zhì)的解讀作用之外，人類和寄生蟲的GST也是細(xì)胞的藥物抗性的首要作用物質(zhì)，而這正是化學(xué)療法失效的主要因素。
Electrophilic alkylating anticancer and antiparasitic drugs have been reported to be either substrates or ligands for the different GST isoenzymes [16], and this forms the basis of cellular drug resistances.
據(jù)報(bào)道，親電子烷化抗癌和抗寄生蟲藥物可以充當(dāng)不同GST同工酶的底物或配體，這一現(xiàn)象構(gòu)成了細(xì)胞藥物抗性的基礎(chǔ)。 |
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