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cainiaodui新蟲 (小有名氣)
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[求助]
翻譯求助
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In preclinical models a number of tumors do not respond at all, or respond initially but become resistant at a late stage of VEGF inhibition . In some experimental cases, such therapy may even increase tumor invasiveness and metastasis . A further problem is that although this therapy is highly specific, patients are not selected on the basis of pathways of sensitivity or resistance in their tumors. Thus, tumor resistance to VEGF inhibition has become a major obstacle to the effectiveness of antiangiogenic agents in the clinic. Clearly, understanding the resistance mechanisms will enhance anti-VEGF efficacy by developing new therapeutic approaches or rational drug combinations |
金蟲 (著名寫手)
| 在臨床前模型中,許多腫瘤完全沒有反應(yīng)或最初有反應(yīng)而在血管內(nèi)皮生長(zhǎng)因子抑制的晚期卻變成抗性的。 在有些實(shí)驗(yàn)病例中,此類療法甚至?xí)吣[瘤侵襲力和轉(zhuǎn)移能力。 另一個(gè)問(wèn)題是,盡管這種療法是非常有特效的,但是患者的選擇不是根據(jù)他們的腫瘤的敏感性或抗性路徑。 因此,腫瘤對(duì)于血管內(nèi)皮生長(zhǎng)因子抑制的抗性已成為臨床中妨礙抗血管新生藥物療效的一種主要因素。顯而易見,了解這種抗性機(jī)理將會(huì)通過(guò)開發(fā)新的治療方法或合理的復(fù)方合劑來(lái)提高血管內(nèi)皮生長(zhǎng)因子抑制劑的功效 |
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