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納米金大牛Rotello課題組最新成果:表面基團(tuán)對納米顆粒胞吐作用的影響
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The Role of Surface Functionality in Nanoparticle Exocytosis Chang Soo Kim, Ngoc D. B. Le,# Yuqing Xing,# Bo Yan, Gulen Yesilbag Tonga, Chaekyu Kim, Richard W. Vachet andVincent M. Rotello* Article first published online: 24 MAR 2014 (# Equal contribution) DOI: 10.1002/adhm.201400001 Abstract Getting out is just as important for nano-therapeutics as getting in. Exocytosis rates determine residency time in the cell, an important determinant for therapeutic efficacy and also for eventual clearance from the cell. In this study, it is shown that exocytosis efficiency is determined by surface functionality, providing a strategy for optimizing nanocarriers. |
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