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cainiaodui新蟲 (小有名氣)
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| The “tip” cell, located at the leading edge of an angiogenic sprout, is highly migratory as evident by the presence of filopodia and expresses high levels of VEGFR-2, VEGFR-3, and platelet-derived growth factor-B. In the retina, the tip cells are thought to require high levels of VEGFR-2 to migrate toward a VEGF gradient produced by the underlying astrocyte plane.The “stalk” cell, located adjacent to the tip cell, is proliferative and lumenizing, and it expresses high levels of VEGFR-1. The cellular mechanisms that differentiate a lumenizing stalk cell from a proliferative stalk cell have yet to be elucidated. |
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