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| Although Notch inhibitors are still preclinical, the monoclonal VEGF antibody bevacizumab is clinically available and represents a potential for combination therapy. As discussed above, some tumors are responsive to VEGF inhibition, although others are unresponsive and become resistant over time.This is most likely due to compensation by other angiogenic pathways that maintain the tumor vasculature. In patients with metastatic breast cancer, treatment with anti-VEGF therapy did not show a statistically significant increase in overall survival benefit.However, combination anti-angiogenic therapy may be useful in overcoming this resistance. |
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| 雖然Notch抑制劑仍然處于臨床前期,抗VEGF單克隆貝伐單抗已用于臨床,并且是聯(lián)合治療及具潛力的方案之一。正如上面的研究,某些腫瘤對(duì)VEGF抑制表現(xiàn)出反應(yīng)性,盡管另外的腫瘤無(wú)反應(yīng)性,并且隨著時(shí)間推移變成抗性。這種情況可能由于其它血管生成途徑保持了腫瘤脈管補(bǔ)償,這種可能性最大。轉(zhuǎn)移性乳腺癌患者,抗VEGF治療未顯示整體存活率有統(tǒng)計(jì)學(xué)意義的顯著增加。然而,聯(lián)合阻撓血管生成的治療對(duì)克服這種抗性有用。 |

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