 |
 |
 |
 |
 |
 |
||
 |
 |
 |
 |
 |
| 1 | 1/1 | 返回列表 |
| 查看: 330 | 回復(fù): 0 | ||
小李小李小李至尊木蟲 (著名寫手)
|
[求助]
誰給翻譯一下呀，謝謝啦
|
|
A mild preparation of substituted indolizines and indole from simple aromatic precursors using (trimethylsilyl)diazomethane In light of the mild conditions and operational simplicity of our indolizine synthesis, we sought to extend the described protocol to the preparation of other heterocycles. Having noted both the presence and proximity of nucleophilic and electrophilic moieties in the 2-(pyridin-2-yl)-acetyl derivatives discussed above, we hypothesized that similarly disposed bifunctional molecules might also prove amenable substrates for heterocycle formation. We were, thus, pleased to discover that 2-aminobenzaldehyde , a bifunctional substrate, could be converted to indole in moderate yield. While the rate of indole formation was slower than that typically observed for the indolizine derivatives described in this Letter, efficient conversion was achieved at 60℃ using 4 equiv of (trimethylsilyl)diazomethane and 2 equiv of Cs2CO3as an alkaline additive.The utility of this method for the synthesis of functionalized indoles is currently under investigation and will be reported in due course. In conclusion, we have developed a mild and convenient method for the synthesis of substituted indolizines from readily available 2-(pyridin-2-yl)acetyl derivatives using (trimethylsilyl)diazomethane in moderate to good yields (41–84%). We have further demonstrated that this reaction can be applied to the synthesis of indole from 2-amino-benzaldehyde and are currently evaluating the feasibility of this synthetic construct for the preparation of substituted indoles and other heterocycles. |
回復(fù)此樓» 猜你喜歡
0854電子信息求調(diào)劑
已經(jīng)有7人回復(fù)
-
0854人工智能方向招收調(diào)劑
已經(jīng)有3人回復(fù)
-
調(diào)劑
已經(jīng)有4人回復(fù)
-
一志愿北化315 求調(diào)劑
已經(jīng)有3人回復(fù)
-
有機(jī)合成求助
已經(jīng)有5人回復(fù)
-
材料學(xué)碩333求調(diào)劑
已經(jīng)有3人回復(fù)
-
289求調(diào)劑
已經(jīng)有7人回復(fù)
-
收08調(diào)劑生
已經(jīng)有6人回復(fù)
-
材料專碩找調(diào)劑
已經(jīng)有5人回復(fù)
-
085602 289分求調(diào)劑
已經(jīng)有5人回復(fù)
相關(guān)版塊跳轉(zhuǎn)
我要訂閱樓主 小李小李小李 的主題更新
| 1 | 1/1 | 返回列表 |
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 289求調(diào)劑 +7 | 碩星赴 2026-03-23 | 7/350 |
|
|---|---|---|---|---|
|
|
[考研] 299求調(diào)劑 +7 | 某某某某位 2026-03-21 | 7/350 |
|
|
[考研] 材料調(diào)劑 +5 | 匹克i 2026-03-23 | 5/250 |
|
|
|
[考研] 材料/農(nóng)業(yè)專業(yè)，07/08開頭均可，過線就行 +3 | 呵唔哦豁 2026-03-23 | 4/200 |
|
|
|
[考研] 化學(xué)308分求調(diào)劑 +3 | 你好明天你好 2026-03-23 | 3/150 |
|
|
|
[考研] 求老師收我 +3 | zzh16938784 2026-03-23 | 3/150 |
|
|
|
[考研] 070300，一志愿北航320求調(diào)劑 +3 | Jerry0216 2026-03-22 | 5/250 |
|
|
|
[考研]
 一志愿東華大學(xué)化學(xué)070300，求調(diào)劑
+7
|
2117205181 2026-03-21 | 8/400 |
|
|
|
[考研] 315分，誠求調(diào)劑，材料與化工085600 +3 | 13756423260 2026-03-22 | 3/150 |
|
|
|
[考研] 308求調(diào)劑 +3 | 墨墨漠 2026-03-21 | 3/150 |
|
|
|
[考研] 一志愿中南化學(xué)（0703）總分337求調(diào)劑 +9 | niko- 2026-03-19 | 10/500 |
|
|
|
[考研] 289求調(diào)劑 +7 | 懷瑾握瑜l 2026-03-20 | 7/350 |
|
|
|
[考研] 0703化學(xué)297求調(diào)劑 +3 | Daisy☆ 2026-03-20 | 3/150 |
|
|
|
[基金申請]
學(xué)校已經(jīng)提交到NSFC，還能修改嗎？
 40+4
|
babangida 2026-03-19 | 9/450 |
|
|
|
[考研] 南昌大學(xué)材料專碩311分求調(diào)劑 +6 | 77chaselx 2026-03-20 | 6/300 |
|
|
|
[考研] 一志愿南昌大學(xué)，327分，材料與化工085600 +9 | Ncdx123456 2026-03-19 | 9/450 |
|
|
|
[考研] 一志愿 西北大學(xué) ，070300化學(xué)學(xué)碩，總分287，雙非一本，求調(diào)劑。 +4 | 晨昏線與星海 2026-03-19 | 4/200 |
|
|
|
[考研] 0817 化學(xué)工程 299分求調(diào)劑 有科研經(jīng)歷 有二區(qū)文章 +22 | rare12345 2026-03-18 | 22/1100 |
|
|
|
[考研] 材料學(xué)求調(diào)劑 +4 | Stella_Yao 2026-03-20 | 4/200 |
|
|
|
[考研] 261求B區(qū)調(diào)劑，科研經(jīng)歷豐富 +3 | 牛奶很忙 2026-03-20 | 4/200 |
|