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malj09新蟲 (小有名氣)
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[求助]
文獻introduction沒怎么看懂求大神指教，，我是學(xué)化學(xué)的里面生物的很不懂 求賜教
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The molecules that have been studied in tissue engineering of bones and cardiosphere derived stem-cell therapy are hydrogen peroxide, sometimes combinedwith catalase,and in the context of pancreatic islet regeneration inorganic peroxides such as calcium peroxide that eventually produce hydrogen peroxide.Soaking of biocompatible polymers such as poly(lactic-co-glycolic acid) (PLGA)has led to promising results, showcasing the possibility to rescue hypoxic tissue and, as a consequence, decrease necrosis of tissue over multiple days in a naked mouse skin flap model. However, an issue can be the cytotoxicity of the H2O2/catalase mixture or, more generally, uncontrolled release of oxygen and ions such as Ca2+. On this account, endoperoxides incorporated into small organic molecules are interesting alternatives owing to their ability to release oxygen in a retro-Diels−Alder reaction following first order kinetics. The reaction rate can likely be controlled by the substitution pattern on the scaffold and does not rely on the presence of enzymes or other triggers. Moreover, these scaffolds could be attached covalently to a solid support, opening up the possibility to synthesize oxygen-releasing polymers with defined rates of oxygen release and without soluble byproducts, such as calcium ions. Systems that have been shown to reversibly incorporate oxygen are derived from polyaromatic hydro- carbons, for example, naphthalene and anthracene or different 2-pyridones. The latter provide a scaffold that allows straightforward generation of interesting substitution patterns, while their polar nature should enhance solubility in watercompared with, for example, anthracene-derived endoper- oxides. Thus, the controlled release of oxygen from substituted 2-pyridone-derived endoperoxides in an aqueous environment followed by subsequent quenching of initially formed 1O2 to 3O2, for example, by solvent deactivation potentially provides a new strategy to rescue anoxic tissue from necrosis. |
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malj09
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3樓2014-05-01 20:30:41
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malj09: 金幣+40, 翻譯EPI+1 2014-05-02 10:20:10
| 骨組織工程和心肌球來源干細(xì)胞治療組織工程中研究的分子為過氧化氫，有時為過氧化氫加過氧化氫酶。胰島內(nèi)再生性無機過氧化物如過氧化鈣，最終產(chǎn)生過氧化氫。生物相容的聚合物如聚乳酸一羥基乙酸共聚物(PLGA)的植入結(jié)果喜人，展示了保全缺氧組織的可能，并且因此減少裸鼠皮瓣移植模型小鼠的組織壞死，皮瓣好多天不會壞死。然而，問題可能出在H2O2/過氧化氫酶混合物的細(xì)胞毒性，或更普遍的是，不受控制的氧和離子如Ca2+的釋放。因為這個原因，摻入有機小分子的內(nèi)過氧化物，由于他們在逆狄爾斯–阿爾德反應(yīng)中按一級動力學(xué)釋放氧氣，這種內(nèi)過氧化物是一種讓人感興趣的替代方案。反應(yīng)速率有可能通過取代有序重疊的反應(yīng)模式控制，并且不依賴于酶或其它觸發(fā)劑。此外，這些有序重疊組群可以共價連接到固體支持物上，開辟了以明確的氧釋放速率合成釋放氧的聚合物，并且沒有不溶性的副產(chǎn)物，如鈣離子。已經(jīng)表現(xiàn)可逆性結(jié)合氧的系統(tǒng)是從聚芳族烴衍生而來，例如，萘和蒽的或不同2 - 吡啶酮。2 - 吡啶酮提供的有序重疊組群，允許讓人感興趣的直接生成取代模式，而它們的極性性質(zhì)，與蒽衍生的內(nèi)過氧化物相比，在水中的溶解度應(yīng)該提高了。水環(huán)境中被取代的2 - 吡啶酮衍生的內(nèi)過氧化物 的可控性氧釋放，隨后進行后期淬滅，淬滅早期形成的1O2到3O2，例如，通過溶劑失活；因此極大地提供了一種全新的辦法來保全缺氧組織不壞死。 |
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