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| The “vascular normalization” hypothesis is a potential resolution of this paradox. The vascular abnormalities in tumors stem from an imbalance between proangiogenic and antiangiogenic factors in the local milieu. The “vascular normalization” hypothesis states that direct or indirect antiangiogenic therapy (usually therapy aimed toneutralize VEGF activity) tips the imbalance between pro- and antiangiogenic factors back toward equilibrium. |
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