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cainiaodui新蟲 (小有名氣)
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[求助]
求助翻譯
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| Movement of molecules across vessel walls occurs by diffusion and convection. Diffusion is governed by concentration gradients across the vessel wall, whereas convection is governed by pressure gradients. To test whether the pressure gradient across the vascular wall improves the penetration of large molecules, we injected fluorescently-labeled BSA i.v. into MCaIV-tumor-bearing mice and observed the pattern of BSA extravasation. We also identified functional blood vessels using biotinylated lectin. Quantitative analysis confirmed that DC101 produced a significantly deeper penetration of BSA molecules into the tumor |
金蟲 (小有名氣)
| 跨血管壁的分子運動主要通過擴散或是對流。擴散的發(fā)生依賴于濃度梯度,然而對流依賴于壓力梯度。為了證明血管兩側(cè)的血壓是否促進分子的大量滲透,我們在 MCaIV-tumor-bearing 小鼠體內(nèi)靜脈注射用熒光標記的BSA,并觀察BSA的滲出模式。我們也使用生物素標記的凝集素確定血管壁的功能。大量實驗分析證實,DC101能使BSA分子更深入地滲透至腫瘤中。 |
至尊木蟲 (文壇精英)
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