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cainiaodui新蟲 (小有名氣)
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| The physiological changes described have a direct effect on solid tumor behavior. Hypoxic tumor cells often show a more aggressive phenotype, activating oncogenes and passing through an “epithelial to mesenchymal transition” (EMT), which heightens their metastatic potential. Moreover, the hostile microenvironment impairs the function of antitumor immune cells, the delivery of which into the tumor is also impaired. Importantly, tumor response to therapy is also impacted. Hypoxia is known to reduce tumor cell sensitivity to radiation and chemotherapy ,and the delivery of systemically administered cytotoxics into tumors is dramatically impeded, especially in areas of low blood flow and raised tumor IFP. It is thus clear that tumor angiogenesis fuels a cascade of microenvironmental abnormalities which can hinder therapeutic outcomes. Reversal of these abnormalities, achieved through “normalizing” tumor vessels, is therefore an intuitively attractive proposition. |
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shiranjiang
金蟲 (正式寫手)
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真強(qiáng)必勝: 金幣+1, 謝謝 2014-05-11 17:03:19
cainiaodui(RXMCDM代發(fā)): 金幣+5 2014-06-08 00:03:48
真強(qiáng)必勝: 金幣+1, 謝謝 2014-05-11 17:03:19
cainiaodui(RXMCDM代發(fā)): 金幣+5 2014-06-08 00:03:48
| 所描述的生理變化對實(shí)體瘤的行為有直接的影響。缺氧的腫瘤細(xì)胞通過激活癌基因和經(jīng)過上皮-間質(zhì)轉(zhuǎn)化(EMT)提高其轉(zhuǎn)移的潛力后往往表現(xiàn)出更積極的表型。此外，敵對的微環(huán)境會損害抗腫瘤免疫細(xì)胞的功能，使進(jìn)入腫瘤的傳遞受損。重要的是,腫瘤的治療也會受到影響。缺氧降低了腫瘤細(xì)胞對放療與化療的敏感性,尤其是在血流量低和腫瘤組織間隙液壓升高的區(qū)域，對系統(tǒng)性執(zhí)行的細(xì)胞毒素進(jìn)入腫瘤的傳遞造成極大的阻礙。由此可見，腫瘤血管生成可導(dǎo)致大量的影響治療結(jié)果的微環(huán)境異常，因此，通過“正常化”腫瘤血管來逆轉(zhuǎn)這些異常是一個具有直觀吸引力的話題。 |
2樓2014-05-11 14:41:40
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