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結(jié)果:哌甲酯在中等劑量下(1.0–2.0 mg/kg,p.o.)顯著改善延遲交替任務(wù)中的表現(xiàn),出現(xiàn)了一條倒U劑量效應(yīng)曲線,而更高劑量(2.0–3.0 mg/kg, p.o.)組的動物出現(xiàn)很多持續(xù)性錯誤。哌甲酯的改善表現(xiàn)作用被α2受體拮抗劑咪唑克生或多巴胺D1拮抗劑SCH23390阻斷,in doses that had no effect on their own. 原文 Results: MPH produced an inverted U dose response whereby moderate doses (1.0–2.0 mg/kg, p.o.) significantly improved delayed alternation performance, while higher doses (2.0–3.0 mg/kg, p.o.) produced perseverative errors in many animals. The enhancing effects of MPH were blocked by co-administration of either the α2 adrenoceptor antagonist, idazoxan, or the dopamine D1 antagonist, SCH23390, in doses that had no effect on their own. in doses that had no effect on their own.是什么意思 |

鐵桿木蟲 (著名寫手)

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