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Nanoparticles (NPs) possess the properties to accomplish tumor targeted drug delivery through enhanced permeability and retention (EPR) effect and targeting strategy. The preferential accumulation of NPs in tumor site could enhance radiation-induced cell-killing capacity in tumor site selectively and reduce the toxicity to normal tissue. Long time retention of NPs in tumor tissue has the potential to support fraction radiation process in fewer doses than their small molecule counterparts. Besides, certain types of NPs could develop the water solubility to avoid the use of polysorbate 80. NPs that consist of docetaxel and a tumor-targeting carrier held great promise for improved radiosensitization. The universality and selectivity of targeting strategies are crucial to the NPs design for radiosensitization. Among these, stimuli-sensitive technology causes the structures of the NPs be transformed by external or internal triggering elements, facilitated drug release and uptake into the tumor cells selectively. |
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RXMCDM: 金幣+1, 多謝應(yīng)助! 2014-10-12 08:31:51
xiaowanzi9: 金幣+25, 翻譯EPI+1, ★★★★★最佳答案, 謝謝，太感謝了~~這么長(zhǎng)都翻譯得這么好 2014-10-13 09:10:58
RXMCDM: 金幣+1, 多謝應(yīng)助! 2014-10-12 08:31:51
xiaowanzi9: 金幣+25, 翻譯EPI+1, ★★★★★最佳答案, 謝謝，太感謝了~~這么長(zhǎng)都翻譯得這么好 2014-10-13 09:10:58
| 納米顆粒（納米粒）所具有的特性，使其可以通過(guò)增強(qiáng)通透性、滯留效應(yīng)（EPR）和靶向定位策略而實(shí)現(xiàn)腫瘤的靶向給藥。納米粒在腫瘤部位的優(yōu)先積累可以提輻射射引起的選擇性腫瘤部位細(xì)胞的殺傷能力，減低對(duì)正常組織毒性。納米顆粒在腫瘤組織中長(zhǎng)時(shí)間的滯留具有支持部分輻射過(guò)程的潛力，與未經(jīng)納米顆粒裝載的小分子輻射物相比可以用更小的劑量。此外，某些類型的納米粒的可開(kāi)發(fā)其水溶解性，以避免使用聚山梨酯。含有多西紫杉醇的納米粒和腫瘤靶向載體希望可以改善其放射增敏作用。定位策略的普遍性和選擇性在設(shè)計(jì)納米顆粒的放射增敏作用中是至關(guān)重要的。其中，刺激敏感技術(shù)使納米粒的結(jié)構(gòu)經(jīng)外部或內(nèi)部觸發(fā)因素而轉(zhuǎn)變，促進(jìn)了藥物釋放和選擇性進(jìn)入腫瘤細(xì)胞中。 |
2樓2014-10-12 02:16:58
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