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腎臟中出現(xiàn)治療相關的作用。特別是發(fā)現(xiàn)腎小管變性/再生的發(fā)病率和嚴重程度有劑量依賴性。 These lesions occurred mainly in the tubules and ducts in the medullary rays and varied in severity from minimal to moderate. The change exhibited mainly as a swelling of the cytoplasm of the tubular epithelial cells with occasiona1 apoptosis and some loss of nuclear staining.Regenerative hyperp1asia of epithelial cells was observed, particularly in more severely affected animals. Tubular degeneration/ regeneration was present diffusely in al1 or most of the medullary rays in some animals and in occasional foci in others. interstitial edema (primarily in the medulla) was observed in some of the more severely affected animals , possibly suggesting an alteration in tubular function. |
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- 翻譯EPI: 1690
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3樓2014-10-22 11:13:05
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5樓2014-10-22 11:59:01
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