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However, the use of copper(II) salts as anticancer drugs presents some drawbacks, which are mainly related to their toxicity and relatively poor bioavailability. To overcome these limitations, copper(II) complexes of multidentate chelate ligands have been evaluated in recent years as alternatives to simple copper salts. In this paper, we report the synthesis of several new copper(II) complexes of various amino acid-derived Schiff base ligands. It is well known that 5-Fluorouracil (5-FU) remains the most commonly used anticancer drug for the treatment of solid tumors, although objective response rates are as low as 20%. Biological activity data showed that the complexes obtained in this study were more cytotoxic than 5-FU against tumor cell lines. 5.jpg |
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- 翻譯EPI: 1690
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- 金幣: 31580.9
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籃球少年: 金幣+12, 翻譯EPI+1, ★★★★★最佳答案, 很不錯(cuò) 2014-11-20 17:44:30
籃球少年: 金幣+12, 翻譯EPI+1, ★★★★★最佳答案, 很不錯(cuò) 2014-11-20 17:44:30
| 然而，使用銅（II）鹽作為抗腫瘤藥物存在一些缺點(diǎn)，主要與它們的毒性和生物利用度比較差有關(guān)。為克服這些限制，近年來，作為簡(jiǎn)單銅鹽的替代物，已經(jīng)對(duì)多齒螯合配位體銅（II）配合物進(jìn)行了評(píng)價(jià)。在本文中，我們報(bào)道的各種氨基酸衍生的席夫堿配體的幾種新銅（II）配合物的合成。眾所周知，5-氟尿嘧啶（5-FU）仍然是用于治療實(shí)體瘤的最常用抗癌藥物，雖然客觀應(yīng)答率低達(dá)20％。生物活性數(shù)據(jù)表明，在本研究中得到的復(fù)合物在抗腫瘤細(xì)胞系中比5-FU的細(xì)胞毒性更大。 |
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