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轉(zhuǎn)身丶忘不掉銅蟲 (小有名氣)
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英語論文翻譯,求助!
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Polymer scaffolds, particularly in the form of microspheres, have been employed to support cells growth and deliver drugs or growth factors in tissue engineering. In this study, we have established a scaffold by embedding poly (β-hydroxybutyrate-co-β-hydroxyvalerate) (PHBV) microspheres into poly (L-lactic-coglycolic acid) (PLGA)matrix, according to their different solubility in acetone, with the aim of repairing bone defects. PLGA/PHBV scaffolds had good pore parameters, for example, the porosity of PLGA/30% PHBV scaffold can reach to 81.273 ± 2.192%. Besides, the pore size distribution of the model was evaluated and the results revealed that the pore size mainly distributed between 50 μm and 200 μm. With increasing the amount of PHBV microspheres, the compressive strength of the PLGA/PHBV scaffold enhanced. The morphology of the hybrid scaffold was rougher than that of pure PLGA scaffold, which had no significant effect on the cell behavior. The in vitro evaluation suggested that the model is suitable as a scaffold for engineering bone tissue, and has the potential for further applications in drug delivery system. |
榮譽版主 (知名作家)
快樂島、布吉島島主
| 高分子支架,特別是微球形式的支架,已在組織工程中被用來支撐細(xì)胞生長以及釋放藥物或生長因子。在本研究中,為了修復(fù)骨損傷,我們發(fā)展了一種制備支架方法,即根據(jù)其在丙酮中溶解性的差異,將PHBV微球包埋在PLGA基質(zhì)中。PLGA/PHBV支架具有良好的孔參數(shù),例如,PLGA/30%PHBV支架的多孔性可達81.273 ± 2.192%。同時,我們也評估了這一模型的孔徑分布,結(jié)果表明孔徑主要分布在50~ 200 μm范圍。通過增加PHBV微球量,此高分子支架的抗壓強度增強了。這種混合型支架的形貌別單純的PLGA支架粗糙,而這一變化對細(xì)胞行為沒有顯著影響。體外評估表明這種模型適用于工程骨組織中的支架,并且在藥物釋放系統(tǒng)的進一步應(yīng)用中具有很大潛力。 |
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