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There are several approaches to promote tissue formation on scaffolds so that it can receive and respond to specific biological signals, which can direct and facilitate cell attachment, proliferation,differentiation and tissue regeneration [26]. Most of them took the idea of improving bioactivity by coating some proteins. For instance, Shen et al. immobilized rhBMP-2 on PLGA films via plasma treatment and found that the immobilized rhBMP-2 can stimulate the differentiation of OCT-1 cell and accelerate its mineralization [27]. Wang et al. immobilized collagen on PHBV surface by chemical treatment to improve chondrocytes compatibility[28]. However, numerous researchers found that micrometric topographies such as grooves and ridges can affect the cell responses because cells can orient themselves along the groove and ridge-so called ‘‘contact guidance’’ [29,30]. Surface topography on the macroscale can also affect tissues such as bone or cartilage significantly [31].
In this work, PHBV microspheres were embedded in a PLGA matrix in order to change the topological structure of the PLGA matrix and enhance the compressive strength of PLGA scaffold. The novel PLGA/PHBV scaffold was prepared using particle-leaching method. The diameters of PHBV microspheres were comparable with the thickness of PLGA matrix walls, which can change the topology of PLGA surface. The morphology, mechanical strength,pore parameters, and human mesenchymal stem cells (hMSCs) compatibility of the new scaffold were evaluated, as well as its ability to support hMSCs. Furthermore, the potential applications of new scaffold model were also discussed.

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1樓 2014-11-20 22:50:02

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轉(zhuǎn)身丶忘不掉: 金幣+15, 翻譯EPI+1, ★★★★★最佳答案, 棒1 2014-11-21 11:17:38

促進(jìn)支架組織形成的方法有多種，如此支架可以接受和反應(yīng)特定的生物信號(hào)，從而引導(dǎo)和促進(jìn)細(xì)胞附著、增殖、分化和組織再生。大多數(shù)方法采用通過包裹某些蛋白質(zhì)來增強(qiáng)生物活性。例如，Shen等通過等離子體處理在PLCA膜上固定rhBMP-2，他們發(fā)現(xiàn)固定的rhBMP-2可刺激OCT-1細(xì)胞的分化，并且加速器礦化。Wang等通過化學(xué)處理在PHBV表面固定膠原蛋白，以提高軟骨細(xì)胞相容性。然而，許多研究者發(fā)現(xiàn)，微米級(jí)的形貌如和脊等可影響細(xì)胞反應(yīng)性，這是因?yàn)榧?xì)胞能沿著這些溝和脊定位自己——所謂的“接觸引導(dǎo)”。宏觀的表面形貌也能顯著地影響骨或軟骨組織。
在我們的工作中，PHBV微球包埋在PLGA基質(zhì)中以改變PLGA基質(zhì)的形貌結(jié)構(gòu)以及增強(qiáng)PLGA支架的抗壓強(qiáng)度。這種新型的ＰＬＧＡ／ＰＨＢＶ支架通過粒子洗出法來制備。ＰＨＢＶ微球的直徑和ＰＬＧＡ的基質(zhì)壁的厚度相當(dāng)，從而可該表ＰＬＧＡ的表面形貌。我們?cè)u(píng)估了新支架的表觀形貌、機(jī)械強(qiáng)度、孔參數(shù)和人類對(duì)ｈＭＳＣ干細(xì)胞的相容性，以及支架支撐ｈＭＳＣ干細(xì)胞的能力。同時(shí)，我們也對(duì)這種新型支架的潛在應(yīng)用加以了討論。

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2樓2014-11-21 09:35:21

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