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The efficacy of doxycycline and ciprofloxacin against an experimental tularaemia infection was assessed by comparing the median lethal dose (MLD) of Francisella tularensis Schu4 biotype A strain given intraperitoneally to antibiotic-treated and untreated mice. In untreated Porton outbred mice this was <1 cfu. Ciprofloxacin and doxycycline given at 40 mg/kg bd, initiated 48 h before infection and continued for 5 days after infection, afforded protection against intraperitoneal challenges of 3.7 x 106 cfu and 6.0 x 106 cfu, respectively. 主要是最后一句話不大懂,intraperitoneal challenges of 3.7 x 106 cfu and 6.0 x 106 cfu。CFU又是什么單位呢?還有,bd應(yīng)該是每日一次的意思吧,可是正文中作者寫的明明是每日給藥兩次:The antibiotics were given twice daily with a 12 h interval between each dose.是不是作者寫錯(cuò)了。? |

木蟲之王 (文學(xué)泰斗)
至尊木蟲 (知名作家)
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Colony-forming unit(CFU):是計(jì)算細(xì)菌數(shù)量的一種方法,其值越高表示樣品中所含的細(xì)菌越多。CFU只計(jì)算活的細(xì)菌。計(jì)算的方式是將一份樣本均勻地涂布在培養(yǎng)皿上,等待菌落生成,再計(jì)算形成的菌落數(shù)目。 在研究造血干細(xì)胞等時(shí),也有一相同的名字:Colony-forming unit(CFU),但中文稱為集落生成單位,主要反應(yīng)的是造血祖細(xì)胞的相對(duì)數(shù)量,以及造血祖細(xì)胞的增殖分化能力。 這里的bd是指每日兩次,正規(guī)的說法是bid,如果每日一次為qd,每日三次為tid,等等。 最后一句話: 感染之前48小時(shí)給藥,持續(xù)給藥至感染后5天,給藥劑量為每日兩次,每次40 mg/kg體重,以保護(hù)對(duì)抗腹腔注射的細(xì)菌,細(xì)菌數(shù)量分別為3.7 x 106 cfu and 6.0 x 106 cfu。 |
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