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Athrun_Zala銅蟲 (小有名氣)
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[求助]
求生物受體類翻譯（英譯中）
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由于小弟對生物領(lǐng)域完全不懂，求大神幫忙翻譯以下內(nèi)容： The nAChRs are homo- or heteromeric pentamers of structurally related subunits that encompass an extracellular N-terminal domain which has six distinct regions (loops A–F) involved in ligand binding, as well as a Cys-Cys loop, four Cterminal transmembrane-spanning domains (TM1–TM4) that form the cation-permeable channel, and an intracellular region extending from TM3 to TM4.[32] Each subunit comprises approximately 500 amino acids, and is encoded by a separate gene, and possesses the four transmembrane domains (TM1–TM4). The subunits are oriented around the central pore, such that the resulting transmembrane ion channel is formed by a pentameric arrangement of the TM2 helical segments contributed by each of the five subunits. In vertebrates, 17 nAChR subunits have been identified (a1– a10, b1–b4, g, d, and e), which can coassemble to generate a diverse family of nAChR subtypes. In insects, several genes have been identified that encode multiple nAChR subunits, which suggests the existence of a range of subtypes of insect receptors across species.[33] As an agonist-gated ion channel complex for excitatory neurotransmission, the nAChR is widely distributed in the insect CNS, and constitutes a major target for insecticide action. Compared to their vertebrate counterparts, the functional architecture, diversity, and threedimensional (3D) tertiary structure of native insect nAChRs are poorly understood.[ |
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【答案】應(yīng)助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ...
Athrun_Zala: 金幣+80, 翻譯EPI+1, ★★★★★最佳答案 2015-03-17 16:36:18
Athrun_Zala: 金幣+80, 翻譯EPI+1, ★★★★★最佳答案 2015-03-17 16:36:18
| nAChRs 是由五個結(jié)構(gòu)相似的亞基組成的同聚體或異聚體, N末端位于胞外, 含有6個明顯的環(huán)狀結(jié)構(gòu)(環(huán)A-F),可與配體結(jié)合. 4個位于C末端的跨膜區(qū)(TM1–TM4)和一個Cys-Cys 環(huán) 形成了一個陽離子的通道. TM3和TM4之間則構(gòu)成了胞內(nèi)區(qū). 每個亞基由獨(dú)立的基因編碼, 長約500個氨基酸,含4個跨膜區(qū)(TM1–TM4). 亞基圍繞一個中心孔排列, 由每個亞基的TM2螺旋結(jié)構(gòu)共同構(gòu)成一個五邊形的跨膜離子通道. 在脊椎動物中, 一共發(fā)現(xiàn)了17 個nAChR亞基 (a1– a10, b1–b4, g, d, and e), 它們按不同組合, 構(gòu)成了多種類型nAChR家族. 在昆蟲中, 數(shù)個編碼nAChR亞基的基因已經(jīng)被發(fā)現(xiàn), 表明存在多個跨種的昆蟲受體類型. 作為一種促效門控離子通道的興奮型離子傳導(dǎo), nAChR廣泛存在于昆蟲的中樞神經(jīng)系統(tǒng)中, 也是殺蟲劑的主要作用靶點(diǎn). 與 脊椎動物的nAChR相比, 昆蟲nAChR的功能性結(jié)構(gòu), 多樣性和三維結(jié)構(gòu)都了解不多. |
2樓2015-03-17 15:38:25
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