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bxzc123

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The microbial transformations of testosterone and testosterone heptanoate by four fungi: Absidia griseolla var. igachii PTCC 5260, Acremonium chrysogenu PTCC 5271, Fusarium fujikuroi PTCC 5144, and Fusarium solani complex PTCC 5285 were investigated for the first time. Incubation of testosterone heptanoate
with F. fujikuroi and F. solani yielded three metabolites, which were isolated and characterized as testosterone, androst-4-ene-3,17-dione, and 6b-hydroxy testosterone. 6b-Hydroxy testosterone was the major metabolite obtained from testosterone heptanoate biotransformation by two fungal species. A. griseolla
and A. chrysogenu produced 14 a -hydroxy testosterone as major metabolite, together with testosterone and 6b-hydroxy testosterone in lower yields. The biotransformation of testosterone by F. fujikuroi and A. griseolla was also investigated in order to examine the influence of the ester group on the course of transformation. Androst-4-ene-3,17-dione was only identified in the biotransformation of testosterone by F. fujikuroi. The same product was observed in incubation of testosterone by A. griseolla, together with
14 a -hydroxy testosterone in very low yield. Furthermore, time course study was also carried out in order to examine the formation of metabolites as a function of time, which was determined by HPLC. The structures of compounds were determined by their comprehensive spectroscopic analysis and comparison with literature data.

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四種真菌對(duì)睪酮和庚酸睪酮的微生物轉(zhuǎn)化：首次對(duì)犁頭霉屬griseolla var. igachii PTCC 5260、枝頂孢屬chrysogenu PTCC 5271、鏈孢霉fujikuroi PTCC 5144和腐皮鐮孢復(fù)合種PTCC 5285進(jìn)行了研究。庚酸睪酮用鐮刀惡苗和茄病鐮刀菌培育得到三種代謝產(chǎn)物,經(jīng)分離并表征為睪酮、雄甾-4-烯-3,17-二酮和6b-羥基睪酮。6b -羥基睪酮是由兩種真菌生物轉(zhuǎn)化庚酸睪酮得到的主要代謝產(chǎn)物。 A. griseolla和A. chrysogenu產(chǎn)生了作為主要代謝產(chǎn)物的14a-羥基睪酮還有較少的睪酮和6b-羥基睪酮。為了檢驗(yàn)酯基對(duì)轉(zhuǎn)化過程的影響，還調(diào)查了用F.fujikuroi（鐮刀惡苗）和A.griseolla對(duì)睪酮的生物轉(zhuǎn)化。在F. fujikuroi（鐮刀惡苗）對(duì)睪酮的生物轉(zhuǎn)化中鑒別出只有雄甾- 4 -烯3,17 -二酮。在用A. griseolla對(duì)睪酮的培育中觀察到相同產(chǎn)物還有極少量的14 a -羥基睪酮。此外,為了考查代謝產(chǎn)物隨時(shí)間函數(shù)的形成情況，還進(jìn)行了時(shí)程研究，通過高效液相色譜進(jìn)行測定。通過對(duì)化合物的廣泛的光譜分析并與文獻(xiàn)資料對(duì)比確定了它們的結(jié)構(gòu)。

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