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重慶大學 生物 張義國教授熱忱歡迎2015級優(yōu)秀碩士考生調劑！
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說明：由于招生名額有限，今年張義國教授團隊未招到計劃人數(shù)，但因主持國家重大計劃集成等項目所需，故向學校申請，剛剛獲批兩個名額，望考生抓緊時間聯(lián)系！ 1.招生類型 碩士招生、接受調劑（2名） 2.招收學校(單位)名稱 重慶大學生物工程學院 3.學制以及何種專業(yè) 三年制學術型碩士，生物學或生物醫(yī)學工程 4. 調劑要求： （1）本科畢業(yè)于“985”、“211”高校； （2）2015年考生原則上總分高于我校相同專業(yè)分數(shù)線10分，單科高于3分（滿分為100分），5分（滿分為150分），條件優(yōu)秀者可以適當放寬； 5.學�；騿挝坏攸c(*必填) 重慶大學（重慶市沙坪壩區(qū)174號） 6.提供的補助待遇(選填) 按學校規(guī)定發(fā)放（實驗室每月另給300－500不等） 7.導師(課題組)介紹(*必填) 研究經(jīng)歷： 1995年獲河南醫(yī)科大學醫(yī)學碩士后留校即任講師，從事單克隆抗體及抗癌疫苗制備和應用研究。1998－2003年間，于美國明尼蘇達(Minnesota)大學，率先研究A類紫外線(UVA)誘導癌變與細胞信號傳導網(wǎng)絡的分子機理。之后，在英國丹迪(Dundee)大學獲細胞生化的哲學博士 (PhD)，留校做CO-PI研究員, 開創(chuàng)了核膜轉錄因子Nrf1及基因調控與癌變的機制研究。2007年被選為英國皇家醫(yī)學協(xié)會Fellow。曾任鄭州大學生物工程系教授，現(xiàn)任重慶大學生物醫(yī)學聯(lián)合學院教授。共發(fā)表90 多項出版物，其中65篇研究論文，多數(shù)發(fā)表于生物化學(JBC, BJ)和癌癥(Cancer Research，Oncogene,Carcinogenesis),及 <Sci Rep_科學報告> 等一流專業(yè)研究期刊上。被SCI他引近2000次，H-指數(shù)33分。英文簡介(http://www.paper.edu.cn/index.ph ... lar/homepage/604116 ). 研究方向： 1）細胞生化和拓撲生物學； 2）癌癥生物學與基因調控； 3）脂肪肝炎惡化為肝癌的分子病理學； 4）Nrf1抗老化與癌變機制及化學防治。 近期研究論文 (*corresponding author), 如下: （具體詳情見http://www.paper.edu.cn/scholar/homepage/604116） Yiguo Zhang*, Yonggang Ren, Shaojun Li, John D Hayes (2014) Transcription Factor Nrf1 Is Topologically Repartitioned across Membranes to Enable Target Gene Transactivation through Its Acidic Glucose-Responsive Domains. PLoS One. 2014 Apr 2;9(4):1-17; e93458. doi: 10.1371/journal.pone.0093458. Michelle A Schultz, Sharika S Hagan, Amrita Datta, Yiguo Zhang, Michael L Freeman, Suresh C Sikka, Asim B Abdel-Mageed, Debasis Mondal (2014) Nrf1 and Nrf2 transcription factors regulate androgen receptor transactivation in prostate cancer cells.PLoS One. 2014 Jan 22;9(1):e87204. doi: 10.1371/journal.pone.0087204. Yiguo Zhang*, Hayes JD (2013) The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity. Sci Rep._Nature.com 3:2006 (1-16). doi: 10.1038/srep02006. H Xiao, F Lü, D Stewart, Yiguo Zhang* (2013) Mechanisms underlying chemopreventive effects of lavonoids via multiple signaling nodes within Nrf2-ARE and AhR-XRE gene regulatory networks. Current Chemical Biology 7 (2): 151-176 Chowdhry S, Yiguo Zhang, McMahon M, Sutherland C, Cuadrado A, Hayes JD (2012-2013) .Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. Oncogene. 2013 Aug 8;32(32):3765-81. Epub 2012 Sep 10. doi:10.1038/onc.2012. 388. PMID:22964642 Julia Li Zhong, Li Yang, Fenglin Lü, Han Xiao, Feifei Tian, Feng Zhu, and YIGUO ZHANG* (2011) UVA, UVB and UVC induce differential response signaling pathways converged on the eIF2a phosphorylation. Photochem. & Photobiol. 87, 1092-1104. Yongjun Wu, Yiming Wu, Jiang Wang, Zhen Yan, Lingbo Qu, Bingren Xiang and YIGUO ZHANG (2011) An optimal tumor marker group-coupled artificial neural network for diagnosis of lung cancer. Expert Systems with Applications 38, 11329-11334. YIGUO ZHANG* and John D. Hayes (2010). Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane. Biochem. J. 430, 497-510. YIGUO ZHANG* (2009). Molecular and cellular control of the Nrf1 transcription factor: An integral membrane glycoprotein. Erschienen bei: VDM Verlag Publishing House Ltd, Germany in May 2009 YIGUO ZHANG*, Akira Kobayashi, Masayuki Yamamoto, and John D. Hayes (2009). The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence. J. Biol. Chem. 284, 3195-3210 YIGUO ZHANG*, John M. Lucocq, and John D. Hayes (2009) The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by tert-butyl hydroquinone but not by endoplasmic reticulum stressors. Biochem. J. 418, 293-310 YIGUO ZHANG*, John M. Lucocq, Masayuki Yamamoto, and John D. Hayes. (2007) The N-terminal homology box 1 (NHB1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation. Biochem. J. 408, 161-172 YIGUO ZHANG*, Dorothy H. Crouch, Masayuki Yamamoto, and John D. Hayes. (2006) Negative regulation of the Nrf1 transcription factor by its N-terminal Domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum. Biochem. J. 399, 373-395 Tatyana A. Zykova, Feng Zhu, YIGUO ZHANG, Ann M. Bode and Zigang Dong. (2007) Involvement of ERKs, RSK2 and PKR in UVA-induced signaling transduction toward phosphorylation of eIF2a. Carcinogenesis 28, 1543-1551 Feng Zhu, Bu Young Choi, Wei-Ya Ma, Zhongliang Zhao, YIGUO ZHANG, Yong Yeon Cho, Hong Seok Choi, Akira Imamoto, Ann M. Bode and Zigang Dong. (2006) COOH-Terminal Src Kinase– Mediated c-Jun Phosphorylation Promotes c-Jun Degradation and Inhibits Cell Transformation. Cancer Research 66, 5729-5736 Yong-Yeon Cho, Zhiwei He, YIGUO ZHANG, Hong Seok Choi, Feng Zhu, Bu Young Choi, Bong Seok Kang, Wei-Ya Ma, Ann M. Bode, and Zigang Dong. (2005) The p53 Protein Is a Novel Substrate of Ribosomal S6 Kinase 2 and a Critical Intermediary for Ribosomal S6 Kinase 2 and Histone H3 Interaction. Cancer Research 65, 3596-3603 Tatyana A. Zykova, YIGUO ZHANG, Feng Zhu, Ann M. Bode, and Zigang Dong (2005). The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols. Carcinogenesis 26(2), 331-342 YIGUO ZHANG, Yong Yeon Cho, Brandon L. Petersen, Feng Zhu, and Zigang Dong. (2004) Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1. Carcinogenesis 25, 1165-1175 YIGUO ZHANG, Yong-Yeon Cho, Brandon L. Petersen, Ann M. Bode, Feng Zhu, and Zigang Dong. (2003). Ataxia telangiectasia mutated protein, MAPKs and RSK2 are involved in the phosphorylation of STAT3. J. Biol. Chem. 278, 12650-12659 YIGUO ZHANG, Wei-Ya Ma, Akira Kaji, Ann M. Bode, and Zigang Dong (2002). Requirement of ATM in UVA-induced signaling and apoptosis. J. Biol. Chem. 277, 3124-3131 YIGUO ZHANG, Guangming Liu, and Zigang Dong (2001). MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells. J. Biol. Chem. 276, 42534-42542 YIGUO ZHANG, Ziming Dong, Masaaki Nomura, Shuping Zhong, Nanyue Chen, Ann M. Bode, and Zigang Dong (2001). Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation. J. Biol. Chem. 276, 20913-20923 YIGUO ZHANG, Shuping Zhong, Ziming Dong, Nanyue Chen, Ann M. Bode, Wei-ya Ma and Zignag Dong (2001). UVA induces Ser381 phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK pathways. J. Biol. Chem. 276, 14572-14580 YIGUO ZHANG, Peter Mttjus, Patricia C. Schmid, Zimng Dong, Shuping Zhong, Wei-Ya Ma, Rhoderick E. Brown, Ann M. Bode, Harald H. O. Schmid, and Zigang Dong (2001). Involvement of the acid sphingomyelinase pathway in UVA-induced apoptosis. J. Biol. Chem. 276, 11775-11782 8.聯(lián)系方式(*必填) Email: yuancaix@126.com |
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