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ygy19901025

木蟲 (著名寫手)

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[求助] 英譯漢，求翻譯，生物、醫(yī)學(xué)方面的

Differentially expressed lncRNAs in PD leukocytes compared to HC. Among all the leukocyte RNA-Seq detected lncRNAs, 13 exhibited differential expression in PD patients compared to matched control volunteers (FDR,0.05). Of these, 8 exhibited disease-mediated decrease, and 5- increase. For each lncRNA, given are is ensEMBL transcript ID, log fold change in PD (pre-DBS) compared to HC, FDR and chromosomal location, as well as the average count read, and count per million (CPM) in the leukocyte sequenced libraries. The brain CPM values are given as well where detected. The predicted targeted miRNAs for the 2 PD leukocyte modified possible competitive endogenous
lncRNAs (ceRNAs) - the U1 small nuclear ribonucleic particle (snRNP) spliceosome component and RP11-462G22.1 (marked with *) are: for U1 - hsa-miR-188-3p, hsa-miR-512-3p, hsa-miR-125b-5p, hsa-miR-1281, hsa-miR-5091, hsamiR-4254, hsa-miR-125a-5p, hsa-miR-4319, and for RP11-462G22.1 - hsa-miR-5093, hsa-miR-877-3p, hsa-miR-27b-5p, hsa-miR-4695-5p, hsa-miR-539-5p, hsa-miR-25-5p, hsa-miR-4730, hsa-miR-4727-3p, hsa-miR-1277-5p, hsa-miR-4307, hsa-miR-29b-2-5p, hsa-miR-3142, hsa-miR-4446-5p, hsa-miR-548t-5p, hsa-miR-3922-5p, hsa-miR-769-5p, hsa-miR-3662, hsa-miR-650, hsa-miR-139-5p, hsa-miR-4494, hsa-miR-3612. Bold: lncRNAs that were also detected as altered in RNA-Seq data from PD patients’ brain samples as compared with HC brains.
#: validated by qRT-PCR in both PD leukocytes and 2 brain regions (Amygdala and Substantia Nigra) of PD and unaffected individuals (the Netherlands Brain Bank).

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1樓 2015-04-19 17:15:04

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yiming_0

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【答案】應(yīng)助回帖

帕金森病人白細(xì)胞中長鏈非編碼RNA與HC相比，在所有的白細(xì)胞RNA測序檢測到的長鏈非編碼RNAs中，其中帕金森病人有13對(duì)與匹配的志愿者展現(xiàn)了差異表達(dá)（FDR,0.05），在這13對(duì)中8對(duì)顯示出現(xiàn)疾病介導(dǎo)的減少，5對(duì)增加。對(duì)于每個(gè)長鏈非編碼RNA，給出的是ENSEMBL轉(zhuǎn)錄的ID，將帕金森病人與HC進(jìn)行日志倍變化的對(duì)比，進(jìn)行FDR和染色體位置的對(duì)比，以及平均讀取數(shù)的對(duì)比，并且在白細(xì)胞序列庫中進(jìn)行每百萬（CPM）計(jì)數(shù)對(duì)比。檢測區(qū)域的大腦CPM值也會(huì)給出。預(yù)測鎖定了2個(gè)帕金森病人白細(xì)胞修改的可能競爭力內(nèi)生的miRNA2。
lncRNAs（ceRNAs） - 的U1小核核糖核酸顆粒（核蛋白）剪接組件和RP11-462G22.1（標(biāo)有*），分別是：為U1 - HSA-的miR-188-3p，HSA-的miR-512-3p，hsa-的miR-125B-5P，HSA-MIR-1281 HSA-MIR-5091，hsamiR-4254，HSA-MIR-125A-5P，HSA-MIR-4319，以及RP11-462G22.1 - HSA-MIR-5093， HSA-的miR-877-3p，HSA-MIR-27B-5P，HSA-MIR-4695-5p，HSA-的miR-539-5p，HSA-MIR-25-5p，HSA-MIR-4730，HSA-miR- 4727-3p，HSA-MIR-1277-5p，HSA-MIR-4307，HSA-MIR-29B-2-5p，HSA-MIR-3142，HSA-MIR-4446-5p，HSA-MIR-548噸-5P， HSA-MIR-3922-5p，HSA-的miR-769-5p，HSA-MIR-3662，HSA-MIR-650，HSA-的miR-139-5p，HSA-MIR-4494，HSA-MIR-3612。
當(dāng)然，同時(shí)也會(huì)檢測帕金森病人與HC大腦取樣中與RMA序列資料不同的長鏈非編碼RNA，
#經(jīng)對(duì)帕金森病人白細(xì)胞和受帕金森影響和未受影響個(gè)體的大腦內(nèi)兩區(qū)域（杏仁核和黑質(zhì)）定量RT-PCR有效驗(yàn)證

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2樓2015-04-20 21:42:49

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