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| Identification of idiosyncratic Mycobacterium tuberculosis ribosomal protein subunits with implications in extraribosomal function, persistence, and drug resistance based on transcriptome data,雜志Journal of biomolecular structure & dynamics |

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Identification of idiosyncratic Mycobacterium tuberculosis ribosomal protein subunits with implications in extraribosomal function, persistence, and drug resistance based on transcriptome data 作者:Fan, XY (Fan, Xiangyu)[ 1 ] ; Tang, XM (Tang, Xiemei)[ 1 ] ; Yan, JL (Yan, Jianlong)[ 1 ] ; Xie, JP (Xie, Jianping)[ 1 ] JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS 卷: 32 期: 10 頁: 1546-1551 DOI: 10.1080/07391102.2013.826143 出版年: 2014 查看期刊信息 摘要 Ribosome, the protein synthesis machinery essential for all living cells, consists of ribosomal proteins and RNA. Extraribosomal functions have recently been discovered for many ribosomal proteins, acting either as individual regulatory proteins or as a complex with other cell components. However, extraribosomal functions of Mycobacterium tuberculosis ribosomal proteins have not been systematically addressed. To this end, M. tuberculosis ribosomal proteins potentially engaged in extraribosomal functions were curated by data mining from transcriptional profiles of M. tuberculosis exposed to diverse treatments. Six M. tuberculosis ribosomal proteins, namely, S3 (Rv0707, rpsC), L16 (Rv0708, rplP), L29 (Rv0709, rpmC), S17 (Rv0710, rpsQ), S14 (Rv2056c, rpsN2), and L33 (Rv2057c, rpmG1), were found to behave idiosyncratically. The function of these abnormal ribosomal subunits can be further explored. Special emphasis is on their potential value as novel targets for better antibiotics. 關(guān)鍵詞 作者關(guān)鍵詞:Mycobacterium tuberculosis; ribosomal proteins; extraribosomal function; data mining KeyWords Plus:GENE-EXPRESSION; ADAPTATION; INSIGHTS 作者信息 通訊作者地址: Xie, JP (通訊作者) 顯示增強(qiáng)組織信息的名稱 Southwest Univ, Minist Educ Ecoenvironm Three Gorges Reservoir Re, State Key Lab Breeding Base Ecoenviroment & Biore, Key Lab,Sch Life Sci,Inst Modern Biopharmaceut, Chongqing 400700, Peoples R China. 地址: 顯示增強(qiáng)組織信息的名稱 [ 1 ] Southwest Univ, Minist Educ Ecoenvironm Three Gorges Reservoir Re, State Key Lab Breeding Base Ecoenviroment & Biore, Key Lab,Sch Life Sci,Inst Modern Biopharmaceut, Chongqing 400700, Peoples R China 電子郵件地址:georgex@swu.edu.cn 基金資助致謝 基金資助機(jī)構(gòu) 授權(quán)號 National Natural Science Foundation 81071316 81271882 National Megaprojects for Key Infectious Diseases 2008ZX10003-006 2012ZX10003-003 New Century Excellent Talents in Universities NCET-11-0703 Excellent PhD thesis fellowship of southwest university kb2009010 ky2011003 Fundamental Research Funds for the Central Universities XDJK2012D011 XDJK2012D007 XDJK2013D003 Natural Science Foundation Project of CQ CSTC 2010BB5002 查看基金資助信息 出版商 TAYLOR & FRANCIS INC, 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA 類別 / 分類 研究方向:Biochemistry & Molecular Biology; Biophysics Web of Science 類別:Biochemistry & Molecular Biology; Biophysics 文獻(xiàn)信息 文獻(xiàn)類型:Article 語種:English 入藏號: WOS:000340120600003 PubMed ID: 23964652 ISSN: 0739-1102 eISSN: 1538-0254 期刊信息 Impact Factor (影響因子): Journal Citation Reports® 其他信息 IDS 號: AM8JP Web of Science 核心合集中的 "引用的參考文獻(xiàn)": 12 Web of Science 核心合集中的 "被引頻次": 0 |

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