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wyying至尊木蟲 (著名寫手)
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潤(rùn)色英文翻譯中文
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Quantifying the vitamin D economy Abstract Vitamin D enters the body through multiple routes and in a variety of chemical forms. Utilization varies with input, demand, and genetics. Vitamin D and its metabolites are carried in the blood on a Gc protein that has three principal alleles with differing binding affinities and ethnic prevalence. Three major metabolites are produced, which act via two routes, endocrine and autocrine/paracrine, and in two compartments, extracellular and intracellular. Metabolic consumption is influenced by physiological controls, noxious stimuli, and tissue demand. When administered as a supplement, varying dosing schedules produce major differences in serum metabolite profiles. To understand vitamin D’s role in human physiology, it is necessary both to identify the foregoing entities, mechanisms, and pathways and, specifically, to quantify them. This review was performed to delineate the principal entities and transitions involved in the vitamin D economy, summarize the status of present knowledge of the applicable rates and masses, draw inferences about functions that are implicit in these quantifications, and point out implications for the determination of adequacy. KEYWORDS: 25-hydroxyvitamin D, 25-dihydroxyvitamin D, inflammation, lactation, obesity, vitamin D 量化維生素D經(jīng)濟(jì) 摘要 維生素D通過多種途徑以不同化學(xué)形式進(jìn)入體內(nèi)。其利用因攝入、需求和遺傳而有所不同。Vitamin D and its metabolites are carried in the blood on a Gc protein that has three principal alleles with differing binding affinities and ethnic prevalence.血液中維生素D及其代謝產(chǎn)物通過Gc球蛋白（因親和力和種族差異有三個(gè)主要的等位基因）進(jìn)行分布。通過兩種代謝途徑（內(nèi)分泌途徑和自分泌/旁分泌途徑）在兩個(gè)區(qū)域（細(xì)胞內(nèi)和細(xì)胞外)生成三種主要的代謝產(chǎn)物。代謝性消耗受生理控制、傷害刺激和組織需求等因素的影響。補(bǔ)充不同劑量的維生素D在血清代謝物特性方面有較大差異。為了理解維生素D在人體生理中的作用，有必要確定前述實(shí)體、作用機(jī)制和途徑，并對(duì)其進(jìn)行量化。This review was performed to delineate the principal entities and transitions involved in the vitamin D economy, summarize the status of present knowledge of the applicable rates and masses, draw inferences about functions that are implicit in these quantifications, and point out implications for the determination of adequacy.本綜述主要闡述維生素D經(jīng)濟(jì)中的主體和演變，概括目前相關(guān)知識(shí)的可適用性和廣泛性，通過對(duì)其生理作用定量分析而進(jìn)行推論，和解釋定量分析所代表的問題。 關(guān)鍵詞：25 -羥基維生素D, 25-二羥基維生素D, 炎癥, 哺乳期, 肥胖, 維生素D |
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wyying
至尊木蟲 (著名寫手)
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