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作者: Zhou Y1, Wang W, Zheng D, Peng S, Xiong W, Ma J, Zeng Z, Wu M, Zhou M, Xiang J, Xiang B, Li X, Li X, Li G 文題: Risk of nasopharyngeal carcinoma associated with polymorphic lactotransferrin haplotypes 期刊名: Med Oncol 期刊年份: 2012 卷(期),起止頁碼: 29(3):1456-62 Doi: doi: 10.1007/s12032-011-0079-6. Epub 2011 Oct 20 |
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Risk of nasopharyngeal carcinoma associated with polymorphic lactotransferrin haplotypes 作者:Zhou, YH (Zhou, Yanhong)[ 1 ] ; Wang, W (Wang, Wei)[ 2 ] ; Zheng, DW (Zheng, Danwei)[ 1 ] ; Peng, SP (Peng, Shuping)[ 1 ] ; Xiong, W (Xiong, Wei)[ 1 ] ; Ma, J (Ma, Jian)[ 1 ] ; Zeng, ZY (Zeng, Zhaoyang)[ 1 ] ; Wu, MH (Wu, Minghua)[ 1 ] ; Zhou, M (Zhou, Ming)[ 1 ] ; Xiang, JJ (Xiang, Juanjuan)[ 1 ] 更多內容 MEDICAL ONCOLOGY 卷: 29 期: 3 頁: 1456-1462 DOI: 10.1007/s12032-011-0079-6 出版年: SEP 2012 查看期刊信息 摘要 Lactotransferrin (LTF) is a component of the nonspecific immune system, having antimicrobial properties against bacteria, fungi, and several viruses. The gene coding for LTF is polymorphic, with the occurrence of several common alleles in the general population. Our previous study found that LTF inhibited nasopharyngeal carcinoma (NPC) cell proliferation in vitro and in vivo. To better understand one possible mechanism of LTF-mediated antitumor activity in NPC cells, in the present study, we investigated the distribution of LTF gene polymorphisms (rs1126477, rs1126478, rs2073495, and rs9110) in NPC and revealed whether these polymorphisms were associated with LTF gene expression. It was found that rs2073495 and rs9110 were correlated significantly with NPC. The frequency of CC genotype was higher and GG or TT genotype was lower, in NPC patients compared with that in the control group (P < 0.05, chi(2) = 8.73 and 9.33, respectively). CC genotype is the risk factor for NPC. Haplotype analyses indicated that NPC patients had lower rate of 'A-G-G-T' haplotype (constructed with rs1126477, rs1126478, rs2073495, and rs9110) compared with controls (P = 4.12 x 10(-6) < 0.001, chi(2) = 21.25). The population with 'A-G-G-T' haplotype had 0.322-fold risk to be NPC. The expression of LTF gene was high in NPC tissues and control tissues with 'A-G-G-T' haplotype compared with these without its. These findings suggested that rs2073495 and rs9110 could play important roles in NPC physiological processes. 關鍵詞 作者關鍵詞:Nasopharyngeal carcinoma; Genetic variation; Haplotype diversity; Lactotransferrin; Gene expression KeyWords Plus:SINGLE-NUCLEOTIDE POLYMORPHISMS; CANDIDATE MOLECULAR MARKERS; HUMAN LACTOFERRIN; GENE-EXPRESSION; RECOMBINANT ADENOVIRUS; SUSCEPTIBILITY LOCUS; MICROARRAY ANALYSIS; TUMOR-SUPPRESSOR; CHROMOSOME 3P21; LINKAGE 作者信息 通訊作者地址: Li, GY (通訊作者) 顯示增強組織信息的名稱 Cent S Univ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China. 地址: 顯示增強組織信息的名稱 [ 1 ] Cent S Univ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China 顯示增強組織信息的名稱 [ 2 ] Cent S Univ, Xiangya Hosp 3, Changsha 410083, Hunan, Peoples R China 電子郵件地址:ligy@xysm.net 基金資助致謝 基金資助機構 授權號 National Natural Sciences Foundation of China 30700469 30871282 30871365 81172189 111 Project 111-2-12 Hunan Province Natural Sciences Foundation of China 10JJ7003 查看基金資助信息 出版商 HUMANA PRESS INC, 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA 類別 / 分類 研究方向:Oncology Web of Science 類別:Oncology 文獻信息 文獻類型:Article 語種:English 入藏號: WOS:000307964100008 PubMed ID: 22011934 ISSN: 1357-0560 期刊信息 目錄： Current Contents Connect® Impact Factor (影響因子): Journal Citation Reports® 其他信息 IDS 號: 994WE Web of Science 核心合集中的 "引用的參考文獻": 41 Web of Science 核心合集中的 "被引頻次": 3 |
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Risk of nasopharyngeal carcinoma associated with polymorphic lactotransferrin haplotypes 作者:Zhou, YH (Zhou, Yanhong)[ 1 ] ; Wang, W (Wang, Wei)[ 2 ] ; Zheng, DW (Zheng, Danwei)[ 1 ] ; Peng, SP (Peng, Shuping)[ 1 ] ; Xiong, W (Xiong, Wei)[ 1 ] ; Ma, J (Ma, Jian)[ 1 ] ; Zeng, ZY (Zeng, Zhaoyang)[ 1 ] ; Wu, MH (Wu, Minghua)[ 1 ] ; Zhou, M (Zhou, Ming)[ 1 ] ; Xiang, JJ (Xiang, Juanjuan)[ 1 ] 更多內容 MEDICAL ONCOLOGY 卷: 29 期: 3 頁: 1456-1462 DOI: 10.1007/s12032-011-0079-6 出版年: SEP 2012 查看期刊信息 摘要 Lactotransferrin (LTF) is a component of the nonspecific immune system, having antimicrobial properties against bacteria, fungi, and several viruses. The gene coding for LTF is polymorphic, with the occurrence of several common alleles in the general population. Our previous study found that LTF inhibited nasopharyngeal carcinoma (NPC) cell proliferation in vitro and in vivo. To better understand one possible mechanism of LTF-mediated antitumor activity in NPC cells, in the present study, we investigated the distribution of LTF gene polymorphisms (rs1126477, rs1126478, rs2073495, and rs9110) in NPC and revealed whether these polymorphisms were associated with LTF gene expression. It was found that rs2073495 and rs9110 were correlated significantly with NPC. The frequency of CC genotype was higher and GG or TT genotype was lower, in NPC patients compared with that in the control group (P < 0.05, chi(2) = 8.73 and 9.33, respectively). CC genotype is the risk factor for NPC. Haplotype analyses indicated that NPC patients had lower rate of 'A-G-G-T' haplotype (constructed with rs1126477, rs1126478, rs2073495, and rs9110) compared with controls (P = 4.12 x 10(-6) < 0.001, chi(2) = 21.25). The population with 'A-G-G-T' haplotype had 0.322-fold risk to be NPC. The expression of LTF gene was high in NPC tissues and control tissues with 'A-G-G-T' haplotype compared with these without its. These findings suggested that rs2073495 and rs9110 could play important roles in NPC physiological processes. 關鍵詞 作者關鍵詞:Nasopharyngeal carcinoma; Genetic variation; Haplotype diversity; Lactotransferrin; Gene expression KeyWords Plus:SINGLE-NUCLEOTIDE POLYMORPHISMS; CANDIDATE MOLECULAR MARKERS; HUMAN LACTOFERRIN; GENE-EXPRESSION; RECOMBINANT ADENOVIRUS; SUSCEPTIBILITY LOCUS; MICROARRAY ANALYSIS; TUMOR-SUPPRESSOR; CHROMOSOME 3P21; LINKAGE 作者信息 通訊作者地址: Li, GY (通訊作者) [顯示增強組織信息的名稱] Cent S Univ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China. 地址: [顯示增強組織信息的名稱] [ 1 ] Cent S Univ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China [顯示增強組織信息的名稱] [ 2 ] Cent S Univ, Xiangya Hosp 3, Changsha 410083, Hunan, Peoples R China 電子郵件地址:ligy@xysm.net 基金資助致謝 基金資助機構 授權號 National Natural Sciences Foundation of China 30700469 30871282 30871365 81172189 111 Project 111-2-12 Hunan Province Natural Sciences Foundation of China 10JJ7003 查看基金資助信息 出版商 HUMANA PRESS INC, 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA 類別 / 分類 研究方向:Oncology Web of Science 類別:Oncology 文獻信息 文獻類型:Article 語種:English 入藏號: WOS:000307964100008 PubMed ID: 22011934 ISSN: 1357-0560 期刊信息 Impact Factor (影響因子): Journal Citation Reports® 其他信息 IDS 號: 994WE Web of Science 核心合集中的 "引用的參考文獻": 41 Web of Science 核心合集中的 "被引頻次": 3 |
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Risk of nasopharyngeal carcinoma associated with polymorphic lactotransferrin haplotypes 作者:Zhou, YH (Zhou, Yanhong)[ 1 ] ; Wang, W (Wang, Wei)[ 2 ] ; Zheng, DW (Zheng, Danwei)[ 1 ] ; Peng, SP (Peng, Shuping)[ 1 ] ; Xiong, W (Xiong, Wei)[ 1 ] ; Ma, J (Ma, Jian)[ 1 ] ; Zeng, ZY (Zeng, Zhaoyang)[ 1 ] ; Wu, MH (Wu, Minghua)[ 1 ] ; Zhou, M (Zhou, Ming)[ 1 ] ; Xiang, JJ (Xiang, Juanjuan)[ 1 ] 更多內容 MEDICAL ONCOLOGY 卷: 29 期: 3 頁: 1456-1462 DOI: 10.1007/s12032-011-0079-6 出版年: SEP 2012 查看期刊信息 摘要 Lactotransferrin (LTF) is a component of the nonspecific immune system, having antimicrobial properties against bacteria, fungi, and several viruses. The gene coding for LTF is polymorphic, with the occurrence of several common alleles in the general population. Our previous study found that LTF inhibited nasopharyngeal carcinoma (NPC) cell proliferation in vitro and in vivo. To better understand one possible mechanism of LTF-mediated antitumor activity in NPC cells, in the present study, we investigated the distribution of LTF gene polymorphisms (rs1126477, rs1126478, rs2073495, and rs9110) in NPC and revealed whether these polymorphisms were associated with LTF gene expression. It was found that rs2073495 and rs9110 were correlated significantly with NPC. The frequency of CC genotype was higher and GG or TT genotype was lower, in NPC patients compared with that in the control group (P < 0.05, chi(2) = 8.73 and 9.33, respectively). CC genotype is the risk factor for NPC. Haplotype analyses indicated that NPC patients had lower rate of 'A-G-G-T' haplotype (constructed with rs1126477, rs1126478, rs2073495, and rs9110) compared with controls (P = 4.12 x 10(-6) < 0.001, chi(2) = 21.25). The population with 'A-G-G-T' haplotype had 0.322-fold risk to be NPC. The expression of LTF gene was high in NPC tissues and control tissues with 'A-G-G-T' haplotype compared with these without its. These findings suggested that rs2073495 and rs9110 could play important roles in NPC physiological processes. 關鍵詞 作者關鍵詞:Nasopharyngeal carcinoma; Genetic variation; Haplotype diversity; Lactotransferrin; Gene expression KeyWords Plus:SINGLE-NUCLEOTIDE POLYMORPHISMS; CANDIDATE MOLECULAR MARKERS; HUMAN LACTOFERRIN; GENE-EXPRESSION; RECOMBINANT ADENOVIRUS; SUSCEPTIBILITY LOCUS; MICROARRAY ANALYSIS; TUMOR-SUPPRESSOR; CHROMOSOME 3P21; LINKAGE 作者信息 通訊作者地址: Li, GY (通訊作者) 顯示增強組織信息的名稱 Cent S Univ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China. 地址: 顯示增強組織信息的名稱 [ 1 ] Cent S Univ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China 顯示增強組織信息的名稱 [ 2 ] Cent S Univ, Xiangya Hosp 3, Changsha 410083, Hunan, Peoples R China 電子郵件地址:ligy@xysm.net 基金資助致謝 基金資助機構 授權號 National Natural Sciences Foundation of China 30700469 30871282 30871365 81172189 111 Project 111-2-12 Hunan Province Natural Sciences Foundation of China 10JJ7003 查看基金資助信息 出版商 HUMANA PRESS INC, 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA 類別 / 分類 研究方向:Oncology Web of Science 類別:Oncology 文獻信息 文獻類型:Article 語種:English 入藏號: WOS:000307964100008 PubMed ID: 22011934 ISSN: 1357-0560 期刊信息 Impact Factor (影響因子): Journal Citation Reports® 其他信息 IDS 號: 994WE Web of Science 核心合集中的 "引用的參考文獻": 41 Web of Science 核心合集中的 "被引頻次": 3 |
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