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peterzc木蟲 (正式寫手)
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[求助]
求大神幫忙翻譯一個摘要，急急急�。。�
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| 膀胱癌是一常見的惡性腫瘤，位列男性最常見實(shí)體瘤第四位。膀胱癌經(jīng)尿道膀胱將腫瘤切除后，需灌注治療以預(yù)防復(fù)發(fā)，其中灌注卡介苗(BCG)被公認(rèn)為預(yù)防膀胱腫瘤術(shù)后復(fù)發(fā)的最佳方法。但該法中，BCG在膀胱中的停留時間僅為1小時，即隨尿液被排出體外，嚴(yán)重影響了其療效，且毒副作用大。前期研究中發(fā)現(xiàn)Co-60γ射線輻照法是一綠色高效的合成技術(shù)，其引發(fā)衣康酸與殼聚糖接枝共聚，產(chǎn)物既有殼聚糖的性能，又賦予其水溶性、靜電紡絲性、吸附性和溫敏性等功能。因此，我們擬用靜電紡絲法或低溫機(jī)械球磨法將其對BCG和磁性Fe3O4進(jìn)行負(fù)載，以便灌注時在體外磁場作用下將BCG實(shí)現(xiàn)靶向貼壁吸附，延長BCG的停留和釋放時間，防止立即隨尿液被排出體外，以及殼聚糖的抑菌性和磁性體在交變磁場作用下的熱效性對BCG的藥效產(chǎn)生協(xié)同作用，均有利于提高BCG藥效而減少其用量，降低毒副作用。本課題研究結(jié)果將為預(yù)防或治療膀胱癌提供新思路和新靶點(diǎn)。 |
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peterzc: 金幣+5, ★★★很有幫助 2015-06-03 18:58:17
peterzc: 金幣+5, ★★★很有幫助 2015-06-03 18:58:17
| Bladder cancer is a common malignant tumor, ranked 4th in the most common solid tumors in males. After the removal of the tumor by bladder transurethral resection , to prevent recurrence, it is necessary to use perfusion treatment. Bacillus Calmette Guerin (BCG) is recognized as one of the best prevention method for recurrence after surgery of bladder cancer. However, one of the shortcoming of this method is the short residence time of BCG in bladder, which only last for 1 hr. That is, it will be flashed away as urine is excreted, limiting its efficacy, and it is associated with some serious side effects. Previous studies found that Co-60 gamma ray irradiation method is a green and efficient method that triggers the cross-linking between itaconic acid and Chitosan, resulting a product that has the properties of chitosan, and provide water-solubility, electrospinning, adsorption and temperature sensitive functionalities.Therefore, we intend to use electrospinning method or low temperature (or cryogenic如果用零下溫度) mechanical milling method to load BCG and magnetic Fe3O4 to the chitosan derivative, in order to achieve targeted adherent adsorption of BCG to the bladder wall perfusion under external magnetic field , to extend the retention and release time of BCG, and to prevent instant flash away along with the urine excretion. The properties of bacteriostasis due to chitosan, and the magnetothermal effect under the action of an alternating magnetic field can produce a synergistic effect that boosts the efficacy of BCG treatment and reduces the dosage needed to minimize side effects. The results of this research will provide new concepts and targets for the prevention and treatment of bladder cancer. |
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