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jndxlm銀蟲 (初入文壇)
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[求助]
請幫忙翻譯,謝謝。在線等
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The interactions between the B3 (catechin-4 R,8-catechin) red wine tannin and the human salivary protein fragment IB714 (SPPGKPQGPPPQGG) were monitored by H magic angle spinning NMR, circular dichroism, electrospray ionization mass spectrometry, and molecular modeling. It is found that the secondary structure of IB7(下標(biāo)14) is made of a type II helix (collagen helix) and random coil. The central glycine 8 appears to act as a flexible rotula separating two helix II regions. Three tannin molecules tightly complex the peptide, without modifying its secondary structure, but seem to reduce its conformational dynamics. The binding dissociation constant is in the millimolar range. B3 tannins with a “tweezers” conformation bind to the hydrophilic side of the saliva peptide, suggesting that the principal driving forces toward association are governed by hydrogen bonding between the carbonyl functions of proline residues and both the phenol and catechol OH groups. These findings are further discussed in the frame of an astringency phenomenon. |
木蟲 (著名寫手)
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在B3(兒茶素4 R,8-兒茶素)紅葡萄酒的單寧和人類唾液蛋白片段IB714(SPPGKPQGPPPQGG)之間的相互作用被用H魔角旋轉(zhuǎn)核磁共振,圓二色性,電噴霧電離質(zhì)譜法,和分子模擬監(jiān)測?芍狪B7(下標(biāo)14)的二級結(jié)構(gòu)是由II型螺旋(膠原螺旋)和無規(guī)卷曲的。中央甘氨酸8似乎充當(dāng)柔性rotula分隔兩個螺旋II區(qū)域。三單寧分子緊緊復(fù)雜 肽,而不需要修改它的二級結(jié)構(gòu),但似乎降低其構(gòu)象動力學(xué)。的結(jié)合解離常數(shù)是在毫摩爾范圍內(nèi)。 B3丹寧帶有“鑷子”構(gòu)象結(jié)合到唾液肽的親水性側(cè),這表明主要驅(qū)動力朝向相關(guān)聯(lián)地由脯氨酸殘基和兩個酚和兒茶酚的OH基的羰基的功能之間的氫鍵的約束。這些發(fā)現(xiàn)在澀味的幀進(jìn)一步討論 現(xiàn)象。 |

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