 |
 |
 |
 |
 |
 |
||
 |
 |
 |
 |
 |
| 1 | 1/1 | 返回列表 |
| 查看: 420 | 回復(fù): 0 | ||
iamlisheng木蟲(chóng) (小有名氣)
|
[求助]
毒理（醫(yī)藥專(zhuān)業(yè)）
|
|
Carcinogenesis Lifetime carcinogenicity studies were conducted in ICR mice and SD rats. Brexpiprazole was administered orally for two years to male and female mice at doses of 0.75, 2 and 5 mg/kg/day (0.9 to 6.1 times the oral MRHD of 4 mg/day based on mg/m2 body surface area) and to male and female rats at doses of 1, 3, and 10 mg/kg and 3, 10, and 30 mg/ kg/day, respectively (2.4 to 24 and 7.3 to 73 times the oral MRHD, males and females). In female mice, the incidence of mammary gland adenocarcinoma was increased at all doses and the incidence of adenosquamous carcinoma was increased at 2.4 and 6.1 times the MRHD. No increase in the incidence of tumors was observed in male mice. In the rat study, brexpiprazole was not carcinogenic in either sex at doses up to 73 times the MRHD. Proliferative and/or neoplastic changes in the mammary and pituitary glands of rodents have been observed following chronic administration of antipsychotic drugs and are considered to be prolactin mediated. The potential for increasing serum prolactin level of brexpiprazole was shown in both mice and rats. The relevance for human risk of the findings of prolactin-mediated endocrine tumors in rodents is unknown. Mutagenesis Brexpiprazole was not mutagenic when tested in the in vitro bacterial reverse mutation assay (Ames test). Brexpiprazole was negative for clastogenic activity in the in vivo micronucleus assay in rats, and was not genotoxic in the in vivo/in vitro unscheduled DNA synthesis assay in rats. In vitro with mammalian cells brexpiprazole was clastogenic but only at doses that induced cytotoxicity. Based on a weight of evidence, brexpiprazole is not considered to present a genotoxic risk to humans. Impairment of Fertility Female rats were treated with oral doses of 0.3, 3 or 30 mg/kg/day (0.7, 7.3, and 73 times the oral MRHD on a mg/m2 basis) prior to mating with untreated males and continuing through conception and implantation. Estrus cycle irregularities and decreased fertility were observed at 3 and 30 mg/kg/day. Prolonged duration of pairing and increased preimplantation losses were observed at 30 mg/kg/day. Male rats were treated with oral doses of 3, 10, or 100 mg/kg/day (7.3, 24 and 240 times the oral MRHD on a mg/m2 basis) for 63 days prior to mating with untreated females and throughout the 14 days of mating. No differences were observed in the duration of mating or fertility indices in males at any dose of brexpiprazole. |
回復(fù)此樓» 猜你喜歡
317求調(diào)劑
已經(jīng)有6人回復(fù)
-
304求調(diào)劑
已經(jīng)有4人回復(fù)
-
085700資源與環(huán)境308求調(diào)劑
已經(jīng)有7人回復(fù)
-
265求調(diào)劑
已經(jīng)有5人回復(fù)
-
279分求調(diào)劑 一志愿211
已經(jīng)有3人回復(fù)
-
求調(diào)劑
已經(jīng)有3人回復(fù)
-
一志愿吉林大學(xué)材料學(xué)碩321求調(diào)劑
已經(jīng)有12人回復(fù)
-
286分人工智能專(zhuān)業(yè)請(qǐng)求調(diào)劑愿意跨考！
已經(jīng)有3人回復(fù)
-
329求調(diào)劑
已經(jīng)有5人回復(fù)
-
申請(qǐng)回稿延期一個(gè)月，編輯同意了。但系統(tǒng)上的時(shí)間沒(méi)變，給編輯又寫(xiě)郵件了，沒(méi)回復(fù)
已經(jīng)有4人回復(fù)
相關(guān)版塊跳轉(zhuǎn)
我要訂閱樓主 iamlisheng 的主題更新
| 1 | 1/1 | 返回列表 |
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 304求調(diào)劑 +4 | 曼殊2266 2026-03-18 | 4/200 |
|
|---|---|---|---|---|
|
[考研] 0856調(diào)劑，是學(xué)校就去 +6 | sllhht 2026-03-19 | 7/350 |
|
|
|
[考博] 申博26年 +3 | 八6八68 2026-03-19 | 3/150 |
|
|
|
[考研] 一志愿西安交通大學(xué)材料工程專(zhuān)業(yè) 282分求調(diào)劑 +5 | 楓橋ZL 2026-03-18 | 7/350 |
|
|
|
[考研] 281求調(diào)劑（0805） +9 | 煙汐憶海 2026-03-16 | 19/950 |
|
|
|
[考研] 332求調(diào)劑 +3 | ydfyh 2026-03-17 | 3/150 |
|
|
|
[考研] 一志愿武理材料305分求調(diào)劑 +5 | 想上岸的鯉魚(yú) 2026-03-18 | 6/300 |
|
|
|
[考研] 化學(xué)工程321分求調(diào)劑 +15 | 大米飯！ 2026-03-15 | 18/900 |
|
|
|
[考研] 331求調(diào)劑（0703有機(jī)化學(xué) +7 | ZY-05 2026-03-13 | 8/400 |
|
|
|
[考研] 302求調(diào)劑 +10 | 呼呼呼。。。。 2026-03-17 | 10/500 |
|
|
|
[考研] 268求調(diào)劑 +8 | 一定有學(xué)上- 2026-03-14 | 9/450 |
|
|
|
[考研] 301求調(diào)劑 +4 | A_JiXing 2026-03-16 | 4/200 |
|
|
|
[考研] 326求調(diào)劑 +5 | 上岸的小葡 2026-03-15 | 6/300 |
|
|
|
[論文投稿] 有沒(méi)有大佬發(fā)小論文能帶我個(gè)二作 +3 | 增銳漏人 2026-03-17 | 4/200 |
|
|
|
[考研] 278求調(diào)劑 +3 | Yy7400 2026-03-13 | 3/150 |
|
|
|
[考研] 333求調(diào)劑 +3 | 文思客 2026-03-16 | 7/350 |
|
|
|
[考研] 277材料科學(xué)與工程080500求調(diào)劑 +3 | 自由煎餅果子 2026-03-16 | 3/150 |
|
|
|
[考研] 070305求調(diào)劑 +3 | mlpqaz03 2026-03-14 | 4/200 |
|
|
|
[考研] 294求調(diào)劑 +3 | Zys010410@ 2026-03-13 | 4/200 |
|
|
|
[考研] 材料與化工 323 英一+數(shù)二+物化，一志愿：哈工大 本人本科雙一流 +4 | 自由的_飛翔 2026-03-13 | 5/250 |
|