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1?????ε??a????Y ??Υ?饒????10??mol/L???u??????133?N???ΙC??????????????塢????????????????????????Τ?????L?????????????????????M1??M2????M3?????塢????????5-HT2?????塢???????????弰??????????????????50????????躦????????????L?????????????????????M1????M3?????塢????????5-HT2????????????IC50????????????????????2.27??1.49??0.80????1.43??mol/L???????? 2????????a????Y ??1????????U??????????????????????Υ?饒???????c????Υ?饒??????0??30??100????600mg/kg?? ?g??U????????????????????Q?????????100mg/kg?????????????600mg/kg???????????????????仯??????6????1?????????????? ??2??????????????????? ??Υ?饒???????c????Υ?饒??????0.5??5????50??g/mL????hERG????躦???????????????0.5??g/mL??????????????hERG??????躦??????IC50????4.8??g/mL??????????o???E????????????R??????????????????????????????????餫?????????????????? ??3?????????????????? ???????????Υ?饒???????c????Υ?饒??????0??30??100????600mg/kg?? ?g??U???????κ??????????Q????????r?Q????????enhanced pause??Penh????????s?????????????????????600mg/kg?????4????8?r?g?????Q?????????r?Q?????ε????????8????4?????????????????????Τ???1????Penh?θ?????????????????????????v?S?????餫?????????? 4??????h????ΙC????I?C????????C??????¤??????Τ??????????????? 5 ?ыD??????路??????????Τ???D?????????????????Σ???????????ж?????????Τ????????????????Y???????????????????R????????40mg/???????????Υ?饒??????????AUC???μs28???????????????????????????P?????ε????????????????T???????β??????????K?????????????????????и???p?????i??????}????????????J?????????? 6 ?????Ф?D?????????????????????????????????????????????????????????????????Y?????????????Ф????Ф????????椵???????? |
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???ε??a????Y ??Υ?饒????10??mol/L???u??????133?N???ΙC??????????????塢????????????????????????Τ?????L?????????????????????M1??M2????M3?????塢????????5-HT2?????塢???????????弰??????????????????50????????躦????????????L?????????????????????M1????M3?????塢????????5-HT2????????????IC50????????????????????2.27??1.49??0.80????1.43??mol/L???????? ??????????? Bonopurazan133?????10??mol/ L?????????????????????壬????????????????????L?????????????M1??M2??M3???壬?????5-HT 2???壬???????50????????????????????????????????á? L?????????????M1??M3???壬??IC 50????????5-HT 2???壬??????2.27,1.49,0.80??1.43??mol/ L?? |
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??????a????Y ??1????????U??????????????????????Υ?饒???????c????Υ?饒??????0??30??100????600mg/kg?? ?g??U????????????????????Q?????????100mg/kg?????????????600mg/kg???????????????????仯??????6????1?????????????? ??2??????????????????? ??Υ?饒???????c????Υ?饒??????0.5??5????50??g/mL????hERG????躦???????????????0.5??g/mL??????????????hERG??????躦??????IC50????4.8??g/mL??????????o???E????????????R??????????????????????????????????餫?????????????????? ????????о? ??1???????????????????????????????????0,30,100??600????/?????Bonopurazan?? ?????????????ο?????????????????????????????100mg/ kg??????????????????????????????600????/????16??????????? ??2???????????????? ???????????????ν??????о?????HERG?????????0.5,5???50??g/ mL?????Bonopurazan???????????????hERG?????????0.5??g??/ mL??????IC 504.8??g/????????? ???????????????????????????????????????????? |
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??3?????????????????? ???????????Υ?饒???????c????Υ?饒??????0??30??100????600mg/kg?? ?g??U???????κ??????????Q????????r?Q????????enhanced pause??Penh????????s?????????????????????600mg/kg?????4????8?r?g?????Q?????????r?Q?????ε????????8????4?????????????????????Τ???1????Penh?θ?????????????????????????v?S?????餫?????????? ??3??????????????? ????????????????????0,30,100??600????/????Bonopurazan?? ???????????ο????????????????????????????????????????饗??????????????????????????600mg/ kg??????4??8С??????4??????????翴??8?????????????????????????????????????????????????????????????????????? |
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