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咖啡卡農(nóng)金蟲 (正式寫手)
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[求助]
Silk Nanoparticles概念分不清
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找到一篇文獻(xiàn)pH-Dependent Anticancer Drug Release from Silk Nanoparticles，其中 Silk Nanoparticles不明白什么意思。cnki上比較多是解釋是絲素納米顆粒，其英文為silk fibroin nanoparticles，感覺這兩個不是一個概念。是不是存在什么絲狀納米顆�；蛐Q絲納米顆粒等等。也查過英文的，多是silk fibroin nanoparticles。不知道二者是否為同一概念，希望專精的前輩給予指點(diǎn)，感激不盡。 以下是摘要部分： Silk has traditionally been used as a suture material because of its excellent mechanical properties and biocompatibility. These properties have led to the development of different silk-based material formats for tissue engineering and regenerative medicine. Although there have been a small number of studies about the use of silk particles for drug delivery, none of these studies have assessed the potential of silk to act as a stimulus-responsive anticancer nanomedicine. This report demonstrates that an acetone precipitation of silk allows the formation of uniform silk nanoparticles (98 nm diameter, polydispersity index 0.109), with an overall negative surface charge (-33.6 +/- 5.8 mV), in a single step. Silk nanoparticles are readily loaded with doxorubicin (40 ng doxorubicin/[mu]g silk) and show pH-dependent release (pH 4.5> 6.0 > 7.4). In vitro studies with human breast cancer cell lines demonstrates that the silk nanoparticles are not cytotoxic (IC50 > 120 [mu]g mL-1) and that doxorubicin-loaded silk nanoparticles are able to overcome drug resistance mechanisms. Live cell fluorescence microscopy studies show endocytic uptake and lysosomal accumulation of silk nanoparticles. In summary, the pH-dependent drug release and lysosomal accumulation of silk nanoparticles demonstrate the ability of drug-loaded silk nanoparticles to serve as a lysosomotropic anticancer nanomedicine. |
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