 |
 |
 |
 |
 |
 |
||
 |
 |
 |
 |
 |
| 5 | 1/1 | 返回列表 |
| 查看: 1144 | 回復: 4 | |||
| 當前只顯示滿足指定條件的回帖，點擊這里查看本話題的所有回帖 | |||
chenyimin_2008銀蟲 (正式寫手)
|
[求助]
對甲苯磺酸索拉非尼的理化性質(zhì) 已有1人參與
|
||
| 各位有默克索引嗎？能否幫我找下對甲苯磺酸的理化性質(zhì)，謝謝啊！ |
回復此樓» 猜你喜歡
見刊快的中文核心期刊
已經(jīng)有2人回復
-
一志愿天中醫(yī)中藥學專碩，希望有b區(qū)的老師可以考慮一下我
已經(jīng)有1人回復
-
藥理學論文潤色/翻譯怎么收費?
已經(jīng)有130人回復
-
調(diào)劑
已經(jīng)有3人回復
-
藥學學碩326求調(diào)劑
已經(jīng)有0人回復
-
26年博士申請
已經(jīng)有20人回復
-
求助 苯磷硫胺JP
已經(jīng)有0人回復
-
100金幣 阿莫西林克拉維酸鉀片BP藥典中提到的克拉維酸聚合物具體結(jié)構(gòu)式是啥？
已經(jīng)有2人回復
-
膳食補充劑合規(guī)性交流
已經(jīng)有0人回復
-
一志愿浙大藥學求調(diào)劑
已經(jīng)有0人回復
-
高溫高壓反應(yīng)求助
已經(jīng)有4人回復
» 本主題相關(guān)價值貼推薦，對您同樣有幫助:
- 對甲苯磺酸索拉非尼質(zhì)量研究
已經(jīng)有4人回復
- 交流一下索拉非尼對甲苯磺酸鹽的顏色
已經(jīng)有7人回復
- 求對甲苯磺酸索拉非尼原料藥的質(zhì)量標準！�。。。。。。。。。。。�！
已經(jīng)有2人回復
- 對甲苯磺酸索拉非尼原料藥的進口標準
已經(jīng)有10人回復
- [求助] 對甲苯磺酸索拉非尼和甲氧芐啶的合成
已經(jīng)有1人回復
- 求助 索拉非尼(Sorafenib,BAY-43-9006)的標準
已經(jīng)有2人回復
- 【求助】求對甲苯磺酸索拉非尼高效液相的流動相，檢測波長，謝謝��！
已經(jīng)有2人回復
癡夷子皮
版主 (文壇精英)
老痞
- DRDEPI: 8
- 應(yīng)助: 2016 (講師)
- 貴賓: 5.368
- 金幣: 54487.3
- 散金: 41688
- 紅花: 303
- 沙發(fā): 1206
- 帖子: 32611
- 在線: 4303.7小時
- 蟲號: 674536
- 注冊: 2008-12-14
- 性別: GG
- 專業(yè): 無神論
- 管轄: 人文社科
|
Title: Sorafenib CAS Registry Number: 284461-73-0 CAS Name: 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide Additional Names: N-4-(Chloro-3-(trifluoromethyl)phenyl)-N¢-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea Manufacturers' Codes: Bay-43-9006 Molecular Formula: C21H16ClF3N4O3 Molecular Weight: 464.82 Percent Composition: C 54.26%, H 3.47%, Cl 7.63%, F 12.26%, N 12.05%, O 10.33% Literature References: Multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Prepn: B. Riedl et al., WO 0041698 (2000 to Bayer); eidem, US 03139605 (2003); D. Bankston et al., Org. Process Res. Dev. 6, 777 (2002). Structure-activity study: U. R. Khire et al., Bioorg. Med. Chem. Lett. 14, 783 (2004). Characterization of kinase inhibition: S. M. Wilhelm et al., Cancer Res. 64, 7099 (2004). Mechanism of action study: D. J. Panka et al., Cancer Res. 66, 1611 (2006). LC determn in serum: S. Afify et al., J. Chromatogr. B 809, 99 (2004). Clinical pharmacokinetics: H. Richly et al., Int. J. Clin. Pharmacol. Ther. 41, 620 (2003). Analysis of clinical safety and efficacy: D. Strumberg et al., Eur. J. Cancer 42, 548 (2006). Clinical evaluation and brief review: H. DeGrendele, Clin. Colorectal Cancer 3, 16-18 (2003). Review of clinical development: B. I. Rini, Expert Opin. Pharmacother. 7, 453-461 (2006). Properties: White solid, mp 205.6°. Melting point: mp 205.6° Derivative Type: Tosylate CAS Registry Number: 475207-59-1 Trademarks: Nexavar (Bayer) Molecular Formula: C21H16ClF3N4O3.C7H8O3S Molecular Weight: 637.03 Percent Composition: C 52.79%, H 3.80%, Cl 5.57%, F 8.95%, N 8.80%, O 15.07%, S 5.03% Therap-Cat: Antineoplastic. Keywords: Antineoplastic; Tyrosine Kinase Inhibitors. |
5樓2015-11-26 12:23:21
癡夷子皮
版主 (文壇精英)
老痞
- DRDEPI: 8
- 應(yīng)助: 2016 (講師)
- 貴賓: 5.368
- 金幣: 54487.3
- 散金: 41688
- 紅花: 303
- 沙發(fā): 1206
- 帖子: 32611
- 在線: 4303.7小時
- 蟲號: 674536
- 注冊: 2008-12-14
- 性別: GG
- 專業(yè): 無神論
- 管轄: 人文社科
【答案】應(yīng)助回帖
感謝參與，應(yīng)助指數(shù) +1
|
Title: p-Toluenesulfonic Acid CAS Registry Number: 104-15-4 CAS Name: 4-Methylbenzenesulfonic acid Additional Names: tosic acid Molecular Formula: C7H8O3S Molecular Weight: 172.20 Percent Composition: C 48.82%, H 4.68%, O 27.87%, S 18.62% Line Formula: CH3C6H4SO3H Literature References: Prepd by sulfonation of toluene with 96-100% H2SO4; when carried out at 75° the compn of the reaction product is 75% para-, 19% ortho- and 6% meta-toluenesulfonic acid. Convenient lab prepn: L. F. Fieser, Experiments in Organic Chemistry (Boston, 3rd ed., 1955) p 144. The separation of toluene from petroleum fractions can be accomplished by sulfonation with H2SO4 at 60°. Properties: Monoclinic leaflets or prisms. Also reported as crystallizing with 1H2O or 4H2O. When anhydrous, mp 106-107°. Metastable form, mp 38°. bp20 140°. bp0.1 185-187°. Freely sol in water, about 67 g/100 ml. Sol in alc and ether. Melting point: mp 106-107°; mp 38° Boiling point: bp20 140°; bp0.1 185-187° Derivative Type: Sodium salt Molecular Formula: C7H7NaO3S Molecular Weight: 194.18 Percent Composition: C 43.30%, H 3.63%, Na 11.84%, O 24.72%, S 16.51% Properties: Orthorhombic plates, very sol in water. CAUTION: Highly irritating to skin, mucous membranes. Use: In dye chemistry; in manuf of oral antidiabetic drugs. |
2樓2015-11-26 10:14:59
3樓2015-11-26 10:37:26
chenyimin_2008
銀蟲 (正式寫手)
- 應(yīng)助: 4 (幼兒園)
- 金幣: 619.9
- 散金: 67
- 紅花: 1
- 帖子: 662
- 在線: 232.6小時
- 蟲號: 496292
- 注冊: 2008-01-17
- 性別: GG
- 專業(yè): 藥物化學
4樓2015-11-26 12:18:12
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 藥學105500求調(diào)劑 +3 | Ssun。。 2026-03-28 | 3/150 |
|
|---|---|---|---|---|
|
|
[考研] 277跪求調(diào)劑 +5 | 1915668 2026-03-27 | 9/450 |
|
|
[考研] 311求調(diào)劑 +8 | lin0039 2026-03-26 | 8/400 |
|
|
|
[考研] 328求調(diào)劑 +7 | 嗯滴的基本都 2026-03-27 | 7/350 |
|
|
|
[考研] 085701環(huán)境工程求調(diào)劑 +9 | 多久上課 2026-03-27 | 9/450 |
|
|
|
[考研] 266分求材料化工冶金礦業(yè)等專業(yè)的調(diào)劑 +4 | 哇呼哼呼哼 2026-03-26 | 4/200 |
|
|
|
[考研]
 一志愿 西北大學 總分282 英語一62 求調(diào)劑
+7
|
18419759900 2026-03-25 | 8/400 |
|
|
|
[考研] 085600，材料與化工321分調(diào)劑 +4 | 大饞小子 2026-03-27 | 6/300 |
|
|
|
[考研] 22408 359分調(diào)劑 +3 | Qshers 2026-03-27 | 3/150 |
|
|
|
[考研] 085600材料與化工306 +10 | z1z2z3879 2026-03-21 | 11/550 |
|
|
|
[考研] 312求調(diào)劑 +9 | 上岸吧ZJY 2026-03-22 | 13/650 |
|
|
|
[考研] 0703化學一志愿南京師范大學303求調(diào)劑 +3 | zzffylgg 2026-03-24 | 3/150 |
|
|
|
[考研] 317求調(diào)劑 +7 | 蛋黃咸肉粽 2026-03-26 | 7/350 |
|
|
|
[考研] 求調(diào)劑 一志愿 本科 北科大 化學 343 +6 | 13831862839 2026-03-24 | 7/350 |
|
|
|
[考研] 334分 一志愿武理 材料求調(diào)劑 +4 | 李李不服輸 2026-03-26 | 4/200 |
|
|
|
[考研] 調(diào)劑310 +3 | 溫柔的晚安 2026-03-25 | 4/200 |
|
|
|
[考研] 生物技術(shù)與工程 +3 | 1294608413 2026-03-25 | 4/200 |
|
|
|
[考研] 求b區(qū)院校調(diào)劑 +4 | 周56 2026-03-24 | 5/250 |
|
|
|
[考研] 化工專碩求調(diào)劑 +3 | question挽風 2026-03-24 | 3/150 |
|
|
|
[考研] 306求0703調(diào)劑一志愿華中師范 +10 | 紙魚ly 2026-03-21 | 11/550 |
|