 |
 |
 |
 |
 |
 |
||
 |
 |
 |
 |
 |
| 1 | 1/1 | 返回列表 |
| 查看: 471 | 回復: 0 | |||
[求助]
求助翻譯下面這段英語翻譯成漢語，急急急
|
| The last two decades have witnessed the emergence of direct enolization protocols providing atom-economical and operationally simple methods to use enolates for stereoselective C–C bond-forming reactions, eliminating the inherent drawback of the preformation of enolates using stoichiometric amounts of reagents. In its infancy, direct enolization relied heavily on the intrinsic acidity of the latent enolates, and the reaction scope was limited to readily enolizable ketones and aldehydes. Recent advances in this field enabled the exploitation of carboxylic acid derivatives for direct enolization, offering expeditious access to synthetically versatile chiral building blocks. Despite the growing demand for enantioenriched fluorine-containing small molecules, α- and β-fluorinated carbonyl compounds have been neglected in direct enolization chemistry because of the competing and dominating defluorination pathway. Herein we present a comprehensive study on direct and highly stereoselective Mannich-type reactions of α- and β-fluorine-functionalized 7-azaindoline amides that rely on a soft Lewis acid/hard Brønsted base cooperative catalytic system to guarantee an efficient enolization while suppressing undesired defluorination. This protocol contributes to provide a series of fluorinated analogs of enantioenriched β-amino acids for medicinal chemistry. |
回復此樓» 猜你喜歡
329求調(diào)劑
已經(jīng)有8人回復
-
070305高分子化學與物理 304分求調(diào)劑
已經(jīng)有8人回復
-
349求調(diào)劑
已經(jīng)有5人回復
-
一志愿北京理工大學本科211材料工程294求調(diào)劑
已經(jīng)有7人回復
-
291求調(diào)劑
已經(jīng)有4人回復
-
0856材料化工調(diào)劑 總分330
已經(jīng)有14人回復
-
352分-085602-一志愿985
已經(jīng)有5人回復
-
各位老師好，我的一志愿為北京科技大學085601材料專碩
已經(jīng)有8人回復
-
求調(diào)劑，一志愿 南京航空航天大學 ，080500材料科學與工程學碩，總分289分
已經(jīng)有4人回復
-
279求調(diào)劑
已經(jīng)有4人回復
相關(guān)版塊跳轉(zhuǎn)
我要訂閱樓主 管曉飛 的主題更新
| 1 | 1/1 | 返回列表 |
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 298求調(diào)劑 +4 | 種圣賜 2026-03-28 | 4/200 |
|
|---|---|---|---|---|
|
|
[考研] 本科雙非材料，跨考一志愿華電085801電氣，283求調(diào)劑，任何專業(yè)都可以 +6 | 芝士雪baoo 2026-03-28 | 8/400 |
|
|
|
[考研] 300求調(diào)劑，材料科學英一數(shù)二 +8 | leaflight 2026-03-24 | 8/400 |
|
|
[碩博家園] 求調(diào)劑 有機化學考研356分 +3 | Nadiums 2026-03-25 | 4/200 |
|
|
|
[考研] 295求調(diào)劑 +4 | wei-5 2026-03-26 | 4/200 |
|
|
|
[考研] 317分 一志愿南理工材料工程 本科湖工大 求調(diào)劑 +7 | 芋泥小鈴鐺 2026-03-28 | 7/350 |
|
|
|
[考研] 0703化學/290求調(diào)劑/本科經(jīng)歷豐富/工科也可 +9 | 丹青奶蓋 2026-03-26 | 10/500 |
|
|
|
[考研] 求調(diào)劑推薦 材料 304 +15 | 荷包蛋hyj 2026-03-26 | 15/750 |
|
|
|
[考研] 一志愿211院校 344分 東北農(nóng)業(yè)大學生物學學碩，求調(diào)劑 +5 | 丶風雪夜歸人丶 2026-03-26 | 8/400 |
|
|
|
[考研] 279 分 求調(diào)劑 +4 | 睡個好覺_16 2026-03-24 | 4/200 |
|
|
|
[考研] 考研化學308分求調(diào)劑 +10 | 你好明天你好 2026-03-23 | 12/600 |
|
|
|
[考研] 085600，材料與化工321分，求調(diào)劑 +9 | 大饞小子 2026-03-27 | 9/450 |
|
|
|
[考研] 化學308分求調(diào)劑 +8 | 你好明天你好 2026-03-23 | 9/450 |
|
|
|
[考研] 324求調(diào)劑 +8 | hanamiko 2026-03-26 | 10/500 |
|
|
|
[考研] 325求調(diào)劑 +5 | 李嘉圖·S·路 2026-03-23 | 5/250 |
|
|
|
[考研] 289求調(diào)劑 +17 | 碩星赴 2026-03-23 | 17/850 |
|
|
|
[考研] 總分293求調(diào)劑 +6 | 加一一九 2026-03-25 | 8/400 |
|
|
|
[考研] 0854電子信息求調(diào)劑 324 +4 | Promise-jyl 2026-03-23 | 4/200 |
|
|
|
[考研] 一志愿武理085500機械專業(yè)總分300求調(diào)劑 +3 | an10101 2026-03-24 | 7/350 |
|
|
|
[考研]
 085404電子信息284分求調(diào)劑
+4
|
13659058978 2026-03-24 | 4/200 |
|