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This report describes the development and scale up of the synthesis of oxaisoxazolidinone 1, a significant synthon in the synthesis of the MRSA development compound AZD5847. Studies were carried out to ensure a short-term, risk based preparation of 9 on a 5 L scale with a solid isolation procedure and a safe, long-term manufacturing process for both 1 and 9 through extensive hazards evaluation. 發(fā)自小木蟲IOS客戶端 |
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4樓2016-01-12 10:52:46
2樓2016-01-11 13:21:59
3樓2016-01-12 08:39:53
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