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敏兒1984新蟲 (初入文壇)
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[求助]
求翻譯摘要2篇,急,謝謝,簡(jiǎn)單翻譯了,請(qǐng)修改
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Non-invasive exhaled volatile organic biomarker analysis to detect inflammatory bowel disease (IBD) 消化道 非侵入性的呼出揮發(fā)性有機(jī)生物標(biāo)志物分析檢測(cè)炎癥性腸病(IBD) Introduction: Early inflammatory bowel disease (IBD) diagnosis remains a clinical challenge. Volatile organic compounds (VOCs) have shown distinct patterns in Crohn’s disease (CD) and ulcerative col-itis (UC). VOC production, reflecting gut fermentome metabolites, is perturbed in IBD. VOC sampling is non-invasive, with various compounds identified from faecal, breath and urine samples. This study aimed to determine if FAIMS (field asymmetric ion mobility spectroscopy) analysis of exhaled VOCs could distinguish IBD from controls. Methods: Seventy-six subjects were recruited, 54 established IBD (25 CD, 29 UC) and 22 healthy con-trols. End expiratory breath was captured using a Warwick device and analysed by FAIMS. Data were pre-processed using wavelet transformation, and classification performed in a 10-fold cross-validation. Feature selection was performed using Wilcoxon rank sum test, and sparse logistic regression gave class predictions, to calculate sensitivity and specificity. Results: FAIMS breath VOC analysis showed clear separation of IBD from controls, sensitivity: 0.74 (0.65–0.82), specificity: 0.75 (0.53–0.90), AUROC: 0.82 (0.74–0.89), p-value 6.2 × 10−7 . IBD subgroup anal-ysis distinguished UC from CD: sensitivity of 0.67 (0.54–0.79), specificity: 0.67 (0.54–0.79), AUROC: 0.70 (0.60–0.80), p-value 9.23 × 10−4 . Conclusion: This confirms the utility of exhaled VOC analysis to distinguish IBD from healthy controls, and UC from CD. It conforms to other studies using different technology, whilst affirming exhaled VOCs as biomarkers for diagnosing IBD.介紹:早期的炎癥性腸。↖BD)的診斷仍然是臨床的挑戰(zhàn)。揮發(fā)性有機(jī)化合物(VOCs)在克羅恩。–D)和潰瘍性結(jié)腸炎的不同模式的關(guān)口,(UC)。揮發(fā)性有機(jī)化合物的生產(chǎn),反映腸道fermentome代謝物,擾動(dòng)在IBD。VOC采樣是非侵入性的,與各種化合物從糞便、呼吸和尿液樣本。本研究的目的是確定如果FAIMS(場(chǎng)非對(duì)稱離子遷移譜)呼出VOCs分析可以區(qū)分IBD對(duì)照。 方法:選取七零六例,54建立IBD(25 CD、UC 29)和22例健康對(duì)照組。呼氣末呼氣使用華威裝置對(duì)FAIMS捕獲。數(shù)據(jù)進(jìn)行預(yù)處理,使用小波變換,并在10倍交叉驗(yàn)證進(jìn)行分類。特征選擇是采用Wilcoxon秩和檢驗(yàn)進(jìn)行,稀疏Logistic回歸了類的預(yù)測(cè),計(jì)算敏感性和特異性。 結(jié)果:呼吸VOC分析表明FAIMS IBD控制,靈敏度明顯分離:0.74(0.65–0.82),特異性0.75(0.53–0.90),下:0.82(0.74–0.89),P值6.2×10−7。IBD亞組分析區(qū)分UC與CD:敏感性0.67,特異性(0.54–0.79):0.67(0.54–0.79),下:0.70(0.60–0.80),P值9.23×10−4。 結(jié)論:這證實(shí)呼出VOC分析區(qū)分IBD健康對(duì)照者的效用,和UC與CD。它符合其他研究使用不同的技術(shù),同時(shí)肯定呼出VOCs作為診斷IBD的生物標(biāo)志物。 |

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