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cainiaodui新蟲 (小有名氣)
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The VEGF-A gene encodes ligands that are involved in orchestrating new blood vessel growth during embryonic and postnatal development, and then in homeostatic survival of endothelial cells, as well as in physiological and pathological situations inthe adult. VEGF signaling via three receptor tyrosine kinases(VEGFR-1–3) is regulated at multiple levels, reflecting thiscomplexity of purpose. Thus, VEGF gene expression can by upregulated both by hypoxia and by oncogene signaling .Additionally, VEGF ligands can be sequestered in the extracellular matrix in latent forms that are subject to release and activation by extracellular matrix-degrading proteasesIn addition, other proangiogenicsignals, such as members of the fibroblast growth factor (FGF)family, have been implicated in sustaining tumor angiogenesiswhen their expression is chronically upregulated |
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Additionally, VEGF ligands can be sequestered in the extracellular matrix in latent forms that are subject to release and activation by extracellular matrix-degrading proteases。 所以說翻譯還是需要一點專業(yè)背景。。。 這里說的意思是,VEGF配體以latent的形式在胞外基質(zhì)中存儲起來,而胞外基質(zhì)降解蛋白酶可以釋放并激活VEGF。 這里的latent,我也不知道翻譯成什么詞合適, 但這個是信號轉(zhuǎn)導(dǎo)中信號分子的一種普遍調(diào)節(jié)機(jī)制,或是通過另外一個蛋白/多肽與信號分子結(jié)合,或是通過信號分子與胞外基質(zhì)成分結(jié)合,這種信號分子是沒有活性而被存儲起來的,只有經(jīng)過蛋白酶把這些與之結(jié)合的成分降解之后才能釋放。 |
金蟲 (小有名氣)
打幾個空格會死嗎……一揮手就貼上來看都不看單詞連在一起了嗎……VEGF-A基因編碼的配體參與了協(xié)調(diào)胚胎期新血管的生長和出生后的發(fā)育、以及之后在成年個體中生理和病理情況下的內(nèi)皮細(xì)胞體內(nèi)穩(wěn)態(tài)生存。三個受體酪氨酸激酶(VEGFR-1-3)對VEGF信號進(jìn)行多水平調(diào)控以反映出其復(fù)雜的功能。因此,組織缺氧和致癌基因信號都能夠促進(jìn)VEGF基因的表達(dá)。此外,VEGF配體能夠以潛伏形態(tài)(??)被隔離在細(xì)胞外基質(zhì)中,這樣是為了通過細(xì)胞外基質(zhì)的降解蛋白酶而被釋放并激活*。另外,其他的粗血管新生的信號,比如FGF家族,當(dāng)其表達(dá)長期的處在上調(diào)狀態(tài)時,會與維持腫瘤血管生成相關(guān)。 *Additionally, VEGF ligands can be sequestered in the extracellular matrix in latent forms that are subject to release and activation by extracellular matrix-degrading proteases。 覺得這個句子that后面相當(dāng)詭異,是我的錯覺嗎……只能按照感覺來翻譯了……以及其他有些語句的表達(dá)也頗為奇特…… |

新蟲 (小有名氣)
新蟲 (小有名氣)
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