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cainiaodui新蟲(chóng) (小有名氣)
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The VEGF-A gene encodes ligands that are involved in orchestrating new blood vessel growth during embryonic and postnatal development, and then in homeostatic survival of endothelial cells, as well as in physiological and pathological situations inthe adult. VEGF signaling via three receptor tyrosine kinases(VEGFR-1–3) is regulated at multiple levels, reflecting thiscomplexity of purpose. Thus, VEGF gene expression can by upregulated both by hypoxia and by oncogene signaling .Additionally, VEGF ligands can be sequestered in the extracellular matrix in latent forms that are subject to release and activation by extracellular matrix-degrading proteasesIn addition, other proangiogenicsignals, such as members of the fibroblast growth factor (FGF)family, have been implicated in sustaining tumor angiogenesiswhen their expression is chronically upregulated |
金蟲(chóng) (小有名氣)
打幾個(gè)空格會(huì)死嗎……一揮手就貼上來(lái)看都不看單詞連在一起了嗎……VEGF-A基因編碼的配體參與了協(xié)調(diào)胚胎期新血管的生長(zhǎng)和出生后的發(fā)育、以及之后在成年個(gè)體中生理和病理情況下的內(nèi)皮細(xì)胞體內(nèi)穩(wěn)態(tài)生存。三個(gè)受體酪氨酸激酶(VEGFR-1-3)對(duì)VEGF信號(hào)進(jìn)行多水平調(diào)控以反映出其復(fù)雜的功能。因此,組織缺氧和致癌基因信號(hào)都能夠促進(jìn)VEGF基因的表達(dá)。此外,VEGF配體能夠以潛伏形態(tài)(??)被隔離在細(xì)胞外基質(zhì)中,這樣是為了通過(guò)細(xì)胞外基質(zhì)的降解蛋白酶而被釋放并激活*。另外,其他的粗血管新生的信號(hào),比如FGF家族,當(dāng)其表達(dá)長(zhǎng)期的處在上調(diào)狀態(tài)時(shí),會(huì)與維持腫瘤血管生成相關(guān)。 *Additionally, VEGF ligands can be sequestered in the extracellular matrix in latent forms that are subject to release and activation by extracellular matrix-degrading proteases。 覺(jué)得這個(gè)句子that后面相當(dāng)詭異,是我的錯(cuò)覺(jué)嗎……只能按照感覺(jué)來(lái)翻譯了……以及其他有些語(yǔ)句的表達(dá)也頗為奇特…… |

新蟲(chóng) (小有名氣)
專家顧問(wèn) (正式寫手)
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專家經(jīng)驗(yàn): +220 |
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Additionally, VEGF ligands can be sequestered in the extracellular matrix in latent forms that are subject to release and activation by extracellular matrix-degrading proteases。 所以說(shuō)翻譯還是需要一點(diǎn)專業(yè)背景。。。 這里說(shuō)的意思是,VEGF配體以latent的形式在胞外基質(zhì)中存儲(chǔ)起來(lái),而胞外基質(zhì)降解蛋白酶可以釋放并激活VEGF。 這里的latent,我也不知道翻譯成什么詞合適, 但這個(gè)是信號(hào)轉(zhuǎn)導(dǎo)中信號(hào)分子的一種普遍調(diào)節(jié)機(jī)制,或是通過(guò)另外一個(gè)蛋白/多肽與信號(hào)分子結(jié)合,或是通過(guò)信號(hào)分子與胞外基質(zhì)成分結(jié)合,這種信號(hào)分子是沒(méi)有活性而被存儲(chǔ)起來(lái)的,只有經(jīng)過(guò)蛋白酶把這些與之結(jié)合的成分降解之后才能釋放。 |
新蟲(chóng) (小有名氣)
新蟲(chóng) (小有名氣)
版主 (文壇精英)
| 血管內(nèi)皮生長(zhǎng)因子-A(Vascular endothelial growth factor-A ,VEGF-A)基因編碼的配體與胚胎期生長(zhǎng)發(fā)育和出生后生長(zhǎng)發(fā)育的新血管生長(zhǎng)有關(guān),與以后的出生后血管內(nèi)皮細(xì)胞自我平衡的生存有關(guān),也成人生理和病理狀況有關(guān)。3種酪氨酸激酶受體(VEGFR-1-3)多水平調(diào)節(jié)調(diào)控VEGF信號(hào)傳導(dǎo),說(shuō)明了調(diào)控的復(fù)雜性。因此,血管內(nèi)皮生長(zhǎng)因子基因表達(dá)既可以通過(guò)缺氧信號(hào)傳導(dǎo)上調(diào),也可以通過(guò)癌基因信號(hào)傳導(dǎo)上調(diào)。此外,血管內(nèi)皮生長(zhǎng)因子配體可隔離于細(xì)胞外基質(zhì)中以無(wú)活性形式存在,這種存在形式在細(xì)胞外基質(zhì)降解蛋白酶作用下釋放或激活。此外,其他促血管生成信號(hào),如成纖維細(xì)胞生長(zhǎng)因子家族成員,其表達(dá)長(zhǎng)期上調(diào)時(shí),與維持腫瘤血管生成有關(guān)。 |

專家顧問(wèn) (正式寫手)
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