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| 結(jié)果顯示：模型組小鼠肺組織中PI3K、AKT1/2及NF-κBp65蛋白的表達(dá)水平在不同時(shí)間均高于正常組（p＜0.05），PI3K、AKT1/2于感染第5天時(shí)表達(dá)最高，NF-κBp65表達(dá)呈持續(xù)增高狀態(tài)。與模型組比較，桑白皮黃酮組小鼠肺組織中PI3K、AKT1/2蛋白的表達(dá)水平在各時(shí)間點(diǎn)顯著降低（p＜0.05），NF-κBp65于感染第5、7天時(shí)表達(dá)水平顯著降低（p＜0.05）；桑白皮多糖組小鼠肺組織中PI3K蛋白的表達(dá)水平于感染第3 、5天時(shí)顯著降低（p＜0.05），AKT1/2蛋白的表達(dá)水平于感染第3、7天時(shí)顯著降低（p＜0.05），NF-κBp65蛋白的表達(dá)水平各時(shí)間點(diǎn)均顯著降低（p＜0.05）。結(jié) 論：1、采用RSV long株經(jīng)鼻腔連續(xù)滴鼻的方法可以成功造出RSV感染幼齡BALB/c小鼠RSV肺炎模型。2、RSV感染小鼠后，可引起小鼠血清IFN-γ、IL-4與肺組織PI3K、AKT1/2及NF-κBp65表達(dá)的改變。3、桑白皮不同有效成分可以調(diào)控RSV肺炎小鼠PI3K/AKT信號(hào)通路與血清IFN-γ、IL-4的表達(dá)，其可能是桑白皮防治RSV肺炎、減輕其炎癥反應(yīng)的作用機(jī)制之一。關(guān)鍵詞：呼吸道合胞病毒（RSV）；BALB/c小鼠；桑白皮；IFN-γ；IL-4；PI3K/AKT/ NF-κB信號(hào)通路；肺炎 |
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genhunter
至尊木蟲 (著名寫手)
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【答案】應(yīng)助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ...
vxiaoxue: 金幣+65, 翻譯EPI+1, ★★★很有幫助, 救急啦，棒棒噠 2016-03-17 20:41:20
vxiaoxue: 金幣+65, 翻譯EPI+1, ★★★很有幫助, 救急啦，棒棒噠 2016-03-17 20:41:20
| The results showed that the levels of PI3K and AKT1 / 2 and NF-κB p65 protein expression on different time were higher in the lung tissue of mice from the model group than those of the normal group (P < 0.05), the expression levels of PI3K and AKT1 / 2 peaked by day 5, while the NF-κB p65 expression was persistently elevated. Compared with the lung tissues from the model group, those from Cortex mori flavonoids-treated (and infected) mice had significantly reduced PI3K and AKT1 / 2 protein expression levels in all time points (P < 0.05), and the NF-κB p65 levels were significantly reduced (P < 0.05) in lungs from the infected mice on days 3, and 5; In Cortex mori polysaccharides-treated mice group, the lung PI3k expression levels were also significantly decreased (P < 0.05) on days 3 and 5 post infection, the expression levels of AKT1 / 2 were significantly reduced (P < 0.05) on days 3 and 7 post infection and , NF-κB p65 protein expression level were significantly lower (P < 0.05) in all time point. Conclusion: 1, successive intranasal infection with the RSV long strains can successfully generate RSV pneumonia model in young BALB / c mice. 2, RSV infection can trigger changes in the levels of serum IFN-γ and IL-4 mice, and PI3K, AKT1/2 and NF-kB p65 expression levels in lung tissue. 3, the white bark from mulberry root have different active ingredients that can regulate the PI3K, Akt signaling pathways and serum IFN gamma, IL-4 expressions in mice with RSV pneumonia, which may be the mechanism of action for Mulberry bark in prevention and treatment of RSV pneumonia, and alleviating the severity of inflammatory reaction. Keywords: respiratory syncytial virus (RSV); BALB / c mice; Mulberry bark; IFN-γ; IL-4; PI3K/AKT/ NFκB signaling pathways; pneumonia |
3樓2016-03-17 20:11:30
4樓2016-03-17 20:56:22
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