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jdy1947

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Thiazole is a heterocyclic organic compound that has a fivemembered
molecular ring structure with molecular formula
C3H3NS. It possesses both an electron-donating group (-S-) and an
electron-accepting group (C]N). It is a stable heterocyclic compound
and has Bird IA value of 79. Thiazole is aromatic on the basis
of delocalization of a lone pair of electrons from the sulphur atom
completing the desirable 6 p electrons to fulfil Huckel's rule. The
thiazole ring is present in many natural and synthetic products
with a broad range of biological activities for example, thiazole
containing vitamin B1 (thiamine) helps in the normal functioning of
the nervous system by its role in the synthesis of acetylcholine [1].
Thiazole ring is highly reactive due to the presence of an acidic
proton at C-2 and has emerged as an important synthon to generate
variety of NCEs (New Chemical Entities). Diverse modifications of
the thiazole ring at various positions led to a variety of novel
compounds with wide spectrum of pharmacological activities such
as antioxidant, antibacterial, antifungal, antitubercular, diuretic,
anti-inflammatory and anticancer activities

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jdy1947: 金幣+50, 翻譯EPI+1, ★★★★★最佳答案 2016-05-03 08:11:31

Thiazole is a heterocyclic organic compound that has a fivemembered molecular ring structure with molecular formula C3H3NS. It possesses both an electron-donating group (-S-) and an electron-accepting group (C]N).
噻唑是一種五節(jié)分子環(huán)結(jié)構有機化合物，分子式為C3H3NS。它既有供電子基團 (-S-)也有電子接受基團(C]N)。

It is a stable heterocyclic compound and has Bird IA value of 79. Thiazole is aromatic on the basis of delocalization of a lone pair of electrons from the sulphur atom completing the desirable 6 p electrons to fulfil Huckel's rule.
作為一種穩(wěn)定的雜環(huán)化合物，噻唑的 Bird IA value（相對原子質(zhì)量？）為79. 噻唑是一種芳香族化合物，在對硫原子的一對孤對電子進行離域作用的基礎上，完成外層硫原子6個電子，從而滿足休克爾規(guī)則。

The thiazole ring is present in many natural and synthetic products with a broad range of biological activities for example, thiazole containing vitamin B1 (thiamine) helps in the normal functioning of the nervous system by its role in the synthesis of acetylcholine [1].
許多自然和合成產(chǎn)品都含有噻唑環(huán)，其涉及的生物活動廣泛例如還有維他命B1的噻唑（硫胺素），因其能夠合成乙酰膽堿，能夠保證神經(jīng)系統(tǒng)的正常功能。

Thiazole ring is highly reactive due to the presence of an acidic proton at C-2 and has emerged as an important synthon to generate variety of NCEs (New Chemical Entities).
因為有一個酸性質(zhì)子存在于C-2上，噻唑環(huán)具有高反應性，同時作為一種重要的合成子，它可以激發(fā)各種新化學實體的生成。

Diverse modifications of the thiazole ring at various positions led to a variety of novel compounds with wide spectrum of pharmacological activities such as antioxidant, antibacterial, antifungal, antitubercular, diuretic,
anti-inflammatory and anticancer activities
對噻唑環(huán)不同部位進行改性處理，可以合成具有各種藥理活性的新型化合物：例如抗氧化劑，抗菌劑，抗真菌劑，抗結(jié)核劑，利尿劑，消炎藥，抗癌藥物。

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