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Thiazole is a heterocyclic organic compound that has a fivemembered molecular ring structure with molecular formula C3H3NS. It possesses both an electron-donating group (-S-) and an electron-accepting group (C]N). It is a stable heterocyclic compound and has Bird IA value of 79. Thiazole is aromatic on the basis of delocalization of a lone pair of electrons from the sulphur atom completing the desirable 6 p electrons to fulfil Huckel's rule. The thiazole ring is present in many natural and synthetic products with a broad range of biological activities for example, thiazole containing vitamin B1 (thiamine) helps in the normal functioning of the nervous system by its role in the synthesis of acetylcholine [1]. Thiazole ring is highly reactive due to the presence of an acidic proton at C-2 and has emerged as an important synthon to generate variety of NCEs (New Chemical Entities). Diverse modifications of the thiazole ring at various positions led to a variety of novel compounds with wide spectrum of pharmacological activities such as antioxidant, antibacterial, antifungal, antitubercular, diuretic, anti-inflammatory and anticancer activities |
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Thiazole is a heterocyclic organic compound that has a fivemembered molecular ring structure with molecular formula C3H3NS. It possesses both an electron-donating group (-S-) and an electron-accepting group (C]N). 噻唑是一種五節(jié)分子環(huán)結(jié)構(gòu)有機化合物,分子式為C3H3NS。 它既有供電子基團 (-S-)也有電子接受基團(C]N)。 It is a stable heterocyclic compound and has Bird IA value of 79. Thiazole is aromatic on the basis of delocalization of a lone pair of electrons from the sulphur atom completing the desirable 6 p electrons to fulfil Huckel's rule. 作為一種穩(wěn)定的雜環(huán)化合物,噻唑的 Bird IA value(相對原子質(zhì)量?)為79. 噻唑是一種芳香族化合物, 在對硫原子的一對孤對電子進行離域作用的基礎(chǔ)上,完成外層硫原子6個電子,從而滿足休克爾規(guī)則。 The thiazole ring is present in many natural and synthetic products with a broad range of biological activities for example, thiazole containing vitamin B1 (thiamine) helps in the normal functioning of the nervous system by its role in the synthesis of acetylcholine [1]. 許多自然和合成產(chǎn)品都含有噻唑環(huán),其涉及的生物活動廣泛例如還有維他命B1的噻唑(硫胺素),因其能夠合成乙酰膽堿,能夠保證神經(jīng)系統(tǒng)的正常功能。 Thiazole ring is highly reactive due to the presence of an acidic proton at C-2 and has emerged as an important synthon to generate variety of NCEs (New Chemical Entities). 因為有一個酸性質(zhì)子存在于C-2上,噻唑環(huán)具有高反應(yīng)性,同時作為一種重要的合成子,它可以激發(fā)各種新化學(xué)實體的生成。 Diverse modifications of the thiazole ring at various positions led to a variety of novel compounds with wide spectrum of pharmacological activities such as antioxidant, antibacterial, antifungal, antitubercular, diuretic, anti-inflammatory and anticancer activities 對噻唑環(huán)不同部位進行改性處理,可以合成具有各種藥理活性的新型化合物:例如抗氧化劑,抗菌劑,抗真菌劑,抗結(jié)核劑,利尿劑,消炎藥,抗癌藥物。 |
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