 |
 |
 |
 |
 |
 |
||
 |
 |
 |
 |
 |
| 2 | 1/1 | 返回列表 |
| 查看: 318 | 回復(fù): 1 | |||
liushuai3788新蟲(chóng) (初入文壇)
|
[交流]
【求助/交流】求翻譯 已有1人參與
|
|
To determine the cell envelope proteins of Borrelia burgdorferi recognized by immune sera of patients with late Lyme disease,we developed a Borrelia microarray containing proteins encoded by 90 cell envelope genes and their homologs described in the annotated genomic sequence of B.burgdorferi,strain B31.The protein microarray was used to profile the humoral immune response using sera from 13 patients with late Lyme disease and four normal controls.Although there was considerable heteroge-neity in the individual sera responses,25 of the cell envelope proteins were recognized by seven or more samples.Sera from non-infected individuals lacked reactivity against any of the proteins on the array. Among the most antigenic envelope proteins,BLAST search revealed little sequence homology to known microbial proteins from other species.The proteins that were highly seropositive included several members of the Erp gene families,BBA24(decorin binding protein A(DbpA))and members of the Borrelia gene family Pfam113 that code for the Mlp lipoprotein gene family.Several novel,uncharac-terized B.burgdorferi antigens identified in this study were BBA14,BBG23,BB0108,BB0442 and BBQ03. The accurate diagnosis of Lyme disease depends on correlating objective clinical abnormalities with serological evidence of exposure to B.burgdorferi.A protein array of the envelope proteins of Borrelia burgdorferi may be very useful in specifically identifying patients with Lyme disease.This approach could contribute to a more rapid discovery of antigens not expressed in vitro that may be useful for the development of vaccine and diagnostics. |
回復(fù)此樓» 猜你喜歡
289材料與化工（085600）B區(qū)求調(diào)劑
已經(jīng)有4人回復(fù)
-
一志愿武理材料工程348求調(diào)劑
已經(jīng)有6人回復(fù)
-
08工科 320總分 求調(diào)劑
已經(jīng)有11人回復(fù)
-
一志愿華中農(nóng)業(yè)071010，總分320求調(diào)劑
已經(jīng)有6人回復(fù)
-
323求調(diào)劑
已經(jīng)有5人回復(fù)
-
284求調(diào)劑
已經(jīng)有5人回復(fù)
-
317求調(diào)劑
已經(jīng)有16人回復(fù)
-
287求調(diào)劑
已經(jīng)有9人回復(fù)
-
求調(diào)劑
已經(jīng)有6人回復(fù)
-
308求調(diào)劑
已經(jīng)有3人回復(fù)
jiwu20
銅蟲(chóng) (小有名氣)
- 應(yīng)助: 0 (幼兒園)
- 金幣: 303.1
- 帖子: 261
- 在線: 22.2小時(shí)
- 蟲(chóng)號(hào): 555479
- 注冊(cè): 2008-05-09
- 專(zhuān)業(yè): 生物大分子結(jié)構(gòu)與功能
★ ★ ★ ★ ★
liushuai3788(金幣+10): 2010-05-01 11:14
amisking(金幣+5): 2010-05-01 12:39
liushuai3788(金幣+10): 2010-05-01 11:14
amisking(金幣+5): 2010-05-01 12:39
|
為了確定病人免疫血清所公認(rèn)的晚期萊姆病萊姆病螺旋體細(xì)胞膜蛋白質(zhì)，我們制定了一個(gè)萊姆芯片包含了90細(xì)胞中的基因和信封注明的B.burgdorferi，應(yīng)變B31座基因序列的同源基因編碼的蛋白質(zhì)的描述。該蛋白芯片，用于配置文件的體液免疫反應(yīng)使用來(lái)自13個(gè)血清 萊姆病晚期和4例正常controls.Although患者有相當(dāng)大的異構(gòu)- neity在個(gè)別血清反應(yīng)，細(xì)胞的膜蛋白有25人承認(rèn)，7個(gè)或更多的非受感染的個(gè)人samples.Sera缺乏對(duì)任何反應(yīng)的蛋白質(zhì)陣列上。 其中最信封蛋白抗原，BLAST搜索發(fā)現(xiàn)很少?gòu)钠渌阎男蛄型葱缘牡鞍踪|(zhì)，具有高度species.The陽(yáng)性微生物蛋白包括幾個(gè) 的ERP基因家族成員，BBA24（核心蛋白聚糖結(jié)合蛋白A（DbpA））和萊姆基因家族Pfam113，對(duì)于總綱發(fā)展藍(lán)圖脂蛋白基因family.Several新穎，uncharac，電導(dǎo)率對(duì)其B.burgdorferi代碼成員抗原這項(xiàng)研究確定出了BBA14 ，BBG23，BB0108，BB0442和BBQ03。 萊姆病的準(zhǔn)確診斷有賴于關(guān)聯(lián)與接觸B.burgdorferi.A對(duì)萊姆病的血清學(xué)包膜蛋白的蛋白質(zhì)陣列客觀證據(jù)臨床異�？赡苁欠浅＞唧w的方式確定與萊姆disease.This患者可能有用 有助于更快速的抗原的發(fā)現(xiàn)，在體外表達(dá)，可能是對(duì)疫苗和診斷的發(fā)展有益。 |
2樓2010-05-01 10:58:49
相關(guān)版塊跳轉(zhuǎn)
我要訂閱樓主 liushuai3788 的主題更新
| 2 | 1/1 | 返回列表 |
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研] 284求調(diào)劑 +5 | Zhao anqi 2026-03-22 | 5/250 |
|
|---|---|---|---|---|
|
|
[考研] 324求調(diào)劑 +6 | lucky呀呀呀鴨 2026-03-20 | 6/300 |
|
|
|
[考研] 298求調(diào)劑一志愿211 +3 | 上岸6666@ 2026-03-20 | 3/150 |
|
|
[考研] 考研調(diào)劑 +4 | 來(lái)好運(yùn)來(lái)來(lái)來(lái) 2026-03-21 | 4/200 |
|
|
|
[考研] 326求調(diào)劑 +5 | 諾貝爾化學(xué)獎(jiǎng)覬?/a> 2026-03-15 | 8/400 |
|
|
|
[考研]
 一志愿東華大學(xué)控制學(xué)碩320求調(diào)劑
+3
|
Grand777 2026-03-21 | 3/150 |
|
|
|
[考研] 材料工程專(zhuān)碩 348分求調(diào)劑 +3 | 冬辭. 2026-03-17 | 5/250 |
|
|
|
[考研] 265求調(diào)劑 +12 | 梁梁校校 2026-03-19 | 14/700 |
|
|
|
[考研] 22 350 本科985求調(diào)劑，求老登收留 +3 | 李軼男003 2026-03-20 | 3/150 |
|
|
|
[考研] 南昌大學(xué)材料專(zhuān)碩311分求調(diào)劑 +6 | 77chaselx 2026-03-20 | 6/300 |
|
|
|
[考研] 一志愿山大07化學(xué) 332分 四六級(jí)已過(guò) 本科山東雙非 求調(diào)劑！ +3 | 不想理你 2026-03-16 | 3/150 |
|
|
|
[考研] 307求調(diào)劑 +3 | wyyyqx 2026-03-17 | 3/150 |
|
|
|
[考研] 一志愿中國(guó)石油大學(xué)（華東） 本科齊魯工業(yè)大學(xué) +3 | 石能偉 2026-03-17 | 3/150 |
|
|
|
[考研] 085700資源與環(huán)境308求調(diào)劑 +12 | 墨墨漠 2026-03-18 | 13/650 |
|
|
|
[考研] 329求調(diào)劑 +9 | 想上學(xué)吖吖 2026-03-19 | 9/450 |
|
|
|
[考研] 085410人工智能專(zhuān)碩317求調(diào)劑（0854都可以） +4 | xbxudjdn 2026-03-18 | 4/200 |
|
|
|
[考研] 081700化工學(xué)碩調(diào)劑 +3 | 【1】 2026-03-16 | 3/150 |
|
|
|
[考研] 286求調(diào)劑 +6 | lemonzzn 2026-03-16 | 10/500 |
|
|
|
[考研] 【同濟(jì)軟件】軟件（085405）考研求調(diào)劑 +3 | 2026eternal 2026-03-18 | 3/150 |
|
|
|
[考研] 070303 總分349求調(diào)劑 +3 | LJY9966 2026-03-15 | 5/250 |
|