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To determine the cell envelope proteins of Borrelia burgdorferi recognized by immune sera of patients with late Lyme disease,we developed a Borrelia microarray containing proteins encoded by 90 cell envelope genes and their homologs described in the annotated genomic sequence of B.burgdorferi,strain B31.The protein microarray was used to profile the humoral immune response using sera from 13 patients with late Lyme disease and four normal controls.Although there was considerable heteroge-neity in the individual sera responses,25 of the cell envelope proteins were recognized by seven or more samples.Sera from non-infected individuals lacked reactivity against any of the proteins on the array. Among the most antigenic envelope proteins,BLAST search revealed little sequence homology to known microbial proteins from other species.The proteins that were highly seropositive included several members of the Erp gene families,BBA24(decorin binding protein A(DbpA))and members of the Borrelia gene family Pfam113 that code for the Mlp lipoprotein gene family.Several novel,uncharac-terized B.burgdorferi antigens identified in this study were BBA14,BBG23,BB0108,BB0442 and BBQ03. The accurate diagnosis of Lyme disease depends on correlating objective clinical abnormalities with serological evidence of exposure to B.burgdorferi.A protein array of the envelope proteins of Borrelia burgdorferi may be very useful in specifically identifying patients with Lyme disease.This approach could contribute to a more rapid discovery of antigens not expressed in vitro that may be useful for the development of vaccine and diagnostics. |
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jiwu20
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liushuai3788(金幣+10): 2010-05-01 11:14
amisking(金幣+5): 2010-05-01 12:39
liushuai3788(金幣+10): 2010-05-01 11:14
amisking(金幣+5): 2010-05-01 12:39
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為了確定病人免疫血清所公認的晚期萊姆病萊姆病螺旋體細胞膜蛋白質(zhì)，我們制定了一個萊姆芯片包含了90細胞中的基因和信封注明的B.burgdorferi，應(yīng)變B31座基因序列的同源基因編碼的蛋白質(zhì)的描述。該蛋白芯片，用于配置文件的體液免疫反應(yīng)使用來自13個血清 萊姆病晚期和4例正常controls.Although患者有相當大的異構(gòu)- neity在個別血清反應(yīng)，細胞的膜蛋白有25人承認，7個或更多的非受感染的個人samples.Sera缺乏對任何反應(yīng)的蛋白質(zhì)陣列上。 其中最信封蛋白抗原，BLAST搜索發(fā)現(xiàn)很少從其他已知的序列同源性的蛋白質(zhì)，具有高度species.The陽性微生物蛋白包括幾個 的ERP基因家族成員，BBA24（核心蛋白聚糖結(jié)合蛋白A（DbpA））和萊姆基因家族Pfam113，對于總綱發(fā)展藍圖脂蛋白基因family.Several新穎，uncharac，電導(dǎo)率對其B.burgdorferi代碼成員抗原這項研究確定出了BBA14 ，BBG23，BB0108，BB0442和BBQ03。 萊姆病的準確診斷有賴于關(guān)聯(lián)與接觸B.burgdorferi.A對萊姆病的血清學包膜蛋白的蛋白質(zhì)陣列客觀證據(jù)臨床異常可能是非常具體的方式確定與萊姆disease.This患者可能有用 有助于更快速的抗原的發(fā)現(xiàn)，在體外表達，可能是對疫苗和診斷的發(fā)展有益。 |
2樓2010-05-01 10:58:49
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